Anti-VEGFB 167抗体[MM0008-7B43] (ab51867)

概述

  • 产品名称Anti-VEGFB 167抗体[MM0008-7B43]
  • 描述
    小鼠单克隆抗体[MM0008-7B43] to VEGFB 167
  • 特异性ab51867 detects both VEGFB 167 and 186 isoforms. No cross reactivity is shown with VEGF, VEGFC and VEGFD.
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human VEGFB 167 recombinant protein.

性能

应用

Our Abpromise guarantee covers the use of ab51867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200. Predicted molecular weight: 22 kDa.
IHC-P 1/25 - 1/100.

靶标

  • 相关性Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB 167 and VEGFB 186. VEGFB 167, a highly basic heparin-binding protein, remains with the cell or extracellular matrix whereas, VEGFB 186 is readily secreted. VEGFB stimulates endothelial cell proliferation. VEGFB binds to the tyrosine kinase receptor VEGFR1 (flt1) and does not bind to VEGFR2. Vascular Endothelial Growth Factor B is widely expressed but is most abundant in heart, skeletal muscle, and pancreas. It has been suggested that VEGFB expression in human primary breast cancers is associated with lymph node metastasis.
  • 细胞定位Secreted protein. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
  • 数据库链接
  • 别名
    • Vascular endothelial growth factor B antibody
    • VEGF B antibody
    • VEGF related factor antibody
    • VEGFL antibody
    • Vrf antibody
    see all

Anti-VEGFB 167 antibody [MM0008-7B43] 图像

  • ab51867 at 1/100 dilution, staining VEGFB 167 in human placenta tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

Anti-VEGFB 167 antibody [MM0008-7B43] (ab51867)参考文献

ab51867 has not yet been referenced specifically in any publications.

Product Wall

I just checked the database and it seems that we had an error when the image was added. Please rest assured that the product was tested in IHC-P and the image is correct. The error was the IHC-Fr application, which was wrongly chosen. It should be ...

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Application Western blot
Sample Cow Tissue lysate - whole (Corpora lutea)
Loading amount 60 µg
Specification Corpora lutea
Gel Running Conditions Reduced Denaturing (Precasted Gel Invitrogen 12% Bis-Tris)
Blocking step BSA as blocking agent for 18 hour(s) and 0 minute(s) · Concentration: 2% · Temperature: 4°C
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提交于 Jul 14 2009

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"