Anti-VEGFA抗体[RM0009-2G02] (ab51653)

概述

  • 产品名称Anti-VEGFA抗体[RM0009-2G02]
    参阅全部 VEGFA 一抗
  • 描述
    大鼠单克隆抗体[RM0009-2G02] to VEGFA
  • 特异性Antibody recognises mouse VEGF 164 and 120
  • 经测试应用适用于: WB, IHC-Frmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Full length native protein (purified) corresponding to Mouse VEGFA.

应用

Our Abpromise guarantee covers the use of ab51653 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/200. Predicted molecular weight: 25 kDa.
IHC-Fr Use at an assay dependent dilution.

靶标

  • 功能Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
  • 组织特异性Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed.
  • 疾病相关Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
  • 序列相似性Belongs to the PDGF/VEGF growth factor family.
  • 细胞定位Secreted. VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC70609 antibody
    • MVCD1 antibody
    • Vascular endothelial growth factor A antibody
    • vascular endothelial growth factor antibody
    • Vascular permeability factor antibody
    • VEGF A antibody
    • Vegf antibody
    • VEGF-A antibody
    • VEGF120 antibody
    • Vegfa antibody
    • VEGFA_HUMAN antibody
    • VPF antibody
    see all

Anti-VEGFA antibody [RM0009-2G02] (ab51653)参考文献

This product has been referenced in:
  • Kawano N  et al. Absence of CD9 reduces endometrial VEGF secretion and impairs uterine repair after parturition. Sci Rep 4:4701 (2014). WB, IHC-Fr ; Mouse . Read more (PubMed: 24736431) »

See 1 Publication for this product

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