概述

  • 产品名称Anti-VEGFA抗体
    参阅全部 VEGFA 一抗
  • 描述
    兔多克隆抗体to VEGFA
  • 特异性Cross reactivity with VEGFA from other sources has not been determined.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Cow
    预测可用于: Mouse, Rat, Sheep, Horse, Guinea pig, Cat, Dog, Human, Pig, Macaque Monkey
  • 免疫原

    Recombinant protein raised in yeast, corresponding to the 164 amino acids of mature Cow VEGFA (NP_776641).

  • 阳性对照
    • Recombinant Cow VEGFA

性能

应用

Our Abpromise guarantee covers the use of ab105846 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/333. Predicted molecular weight: 19.2 kDa.
ELISA Use at an assay dependent concentration.

靶标

  • 功能Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
  • 组织特异性Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed.
  • 疾病相关Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:603933]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
  • 序列相似性Belongs to the PDGF/VEGF growth factor family.
  • 细胞定位Secreted. VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC70609 antibody
    • MVCD1 antibody
    • Vascular endothelial growth factor A antibody
    • vascular endothelial growth factor antibody
    • Vascular permeability factor antibody
    • VEGF A antibody
    • Vegf antibody
    • VEGF-A antibody
    • VEGF120 antibody
    • Vegfa antibody
    • VEGFA_HUMAN antibody
    • VPF antibody
    see all

Anti-VEGFA antibody 图像

  • Anti-VEGFA antibody (ab105846) at 1/333 dilution + Recombinant cow VEGFA at 2 µg

    Secondary
    IRDye™800 Conjugated Affinity Purified Goat-anti-Rabbit IgG [H&L] at 1/10000 dilution

    Predicted band size : 19.2 kDa

Anti-VEGFA antibody (ab105846)参考文献

ab105846 has not yet been referenced specifically in any publications.

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