Anti-VEGF Receptor 2抗体[3D09] (ab42230)
Key features and details
- Rat monoclonal [3D09] to VEGF Receptor 2
- Suitable for: Functional Studies
- Reacts with: Mouse
- Isotype: IgG2a
概述
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产品名称
Anti-VEGF Receptor 2抗体[3D09]
参阅全部 VEGF Receptor 2 一抗 -
描述
大鼠单克隆抗体[3D09] to VEGF Receptor 2 -
宿主
Rat -
特异性
This antibody shows no cross-reactivity with VEGF Receptor 1. -
经测试应用
适用于: Functional Studiesmore details -
种属反应性
与反应: Mouse -
免疫原
Purified fragment, corresponding to N terminal amino acids 30-200 of Mouse VEGF Receptor 2
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阳性对照
- Mouse skin endothelial cells (mSENDs)
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Concentration information loading...
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纯度
Protein G purified -
克隆
单克隆 -
克隆编号
3D09 -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab42230于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Functional Studies |
Use a concentration of 1 - 5 µg/ml. Can induce VEGF Receptor 2 tyrosine phosphorylation in mouse skin endothelial cells.
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说明 |
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Functional Studies
Use a concentration of 1 - 5 µg/ml. Can induce VEGF Receptor 2 tyrosine phosphorylation in mouse skin endothelial cells. |
靶标
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功能
Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. -
疾病相关
Defects in KDR are associated with susceptibility to hemangioma capillary infantile (HCI) [MIM:602089]. HCI are benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium. They are the most common tumor of infancy, occurring in up to 10% of all births. Hemangiomas tend to appear shortly after birth and show rapid neonatal growth for up to 12 months characterized by endothelial hypercellularity and increased numbers of mast cells. This phase is followed by slow involution at a rate of about 10% per year and replacement by fibrofatty stroma. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
翻译后修饰
Phosphorylated. Dephosphorylated by PTPRB. Dephosphorylated by PTPRJ at Tyr-951, Tyr-996, Tyr-1054, Tyr-1059, Tyr-1175 and Tyr-1214. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 16542 Mouse
- SwissProt: P35918 Mouse
- Unigene: 285 Mouse
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别名
- CD309 antibody
- CD309 antigen antibody
- EC 2.7.10.1 antibody
see all
图片
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (1)
ab42230 被引用在 1 文献中.
- Yu CQ et al. Vascular endothelial growth factor mediates corneal nerve repair. Invest Ophthalmol Vis Sci 49:3870-8 (2008). PubMed: 18487369