Anti-VEGF Receptor 1抗体[AP-MAB0702] (ab56300)


  • 产品名称Anti-VEGF Receptor 1抗体[AP-MAB0702]
    参阅全部 VEGF Receptor 1 一抗
  • 描述
    小鼠单克隆抗体[AP-MAB0702] to VEGF Receptor 1
  • 经测试应用适用于: WB, Blockingmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant fragment (Human): the purified extracellular domain of recombinant human VEGFR1

  • 阳性对照
    • Human and mouse endothelial cell lysate.



Our Abpromise guarantee covers the use of ab56300 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/400 - 1/1000. Detects a band of approximately 200 kDa (predicted molecular weight: 151 kDa).
Blocking Use a concentration of 5 - 15 µg/ml. Used to block VEGF induced VGFR! Tyrosine phosphorylation in HUVEC and mouse endothelial cells.


  • 功能Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.
  • 组织特异性Mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform sFlt1 is strongly expressed in placenta.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 细胞定位Secreted and Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • EC antibody
    • FLT 1 antibody
    • FLT antibody
    • Flt-1 antibody
    • FLT1 antibody
    • Fms like tyrosine kinase 1 antibody
    • Fms related tyrosine kinase 1 antibody
    • Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody
    • Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor antibody
    • Fms-like tyrosine kinase 1 antibody
    • FRT antibody
    • Soluble VEGF receptor 1 14 antibody
    • Soluble VEGFR1 variant 2 antibody
    • Soluble VEGFR1 variant 21 antibody
    • Tyrosine protein kinase FRT antibody
    • Tyrosine protein kinase receptor FLT antibody
    • Tyrosine-protein kinase FRT antibody
    • Tyrosine-protein kinase receptor FLT antibody
    • Vascular endothelial growth factor receptor 1 antibody
    • Vascular endothelial growth factor vascular permeability factor receptor antibody
    • Vascular permeability factor receptor 1 antibody
    • Vascular permeability factor receptor antibody
    • VEGFR 1 antibody
    • VEGFR-1 antibody
    • VEGFR1 antibody
    • VGFR1_HUMAN antibody
    see all

Anti-VEGF Receptor 1 antibody [AP-MAB0702] (ab56300)参考文献

This product has been referenced in:
  • Chidlow JH  et al. VEGF164 differentially regulates neutrophil and T cell adhesion through ItgaL- and ItgaM-dependent mechanisms. Am J Physiol Gastrointest Liver Physiol 299:G1361-7 (2010). Blocking ; Mouse . Read more (PubMed: 20884890) »
  • Ptaszynska MM  et al. Positive Feedback between Vascular Endothelial Growth Factor-A and Autotaxin in Ovarian Cancer Cells. Mol Cancer Res 6:352-63 (2008). Read more (PubMed: 18337445) »

See all 2 Publications for this product

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Thank you for your enquiry.

At this time Idon't have any western blotting data which could address the issue you are seeing. And although the epitope recognized by ab56300 is not mapped, it does appear to involve a discontinuous epitope forme...

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Thank you for your enquiry. In brief, HUVECs were stimulated with VEGF (30ng/ml) for 20mins to induce VEGFR1 phosphorylation. In blocking experiments, HUVECs were pre-incubated antibody at 5 or 15ug/ml for 20mins before stimulated with VEGF (30ng/m...

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