Anti-VE Cadherin抗体[BV13] - Intercellular Junction Marker (ab91064)
Key features and details
- Rat monoclonal [BV13] to VE Cadherin - Intercellular Junction Marker
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Isotype: IgG1
概述
-
产品名称
Anti-VE Cadherin抗体[BV13] - Intercellular Junction Marker
参阅全部 VE Cadherin 一抗 -
描述
大鼠单克隆抗体[BV13] to VE Cadherin - Intercellular Junction Marker -
宿主
Rat -
经测试应用
适用于: Flow Cytmore details -
种属反应性
与反应: Mouse -
免疫原
Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.
-
阳性对照
- bEnd.3 cells
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading...
-
纯度
Protein A purified -
克隆
单克隆 -
克隆编号
BV13 -
同种型
IgG1 -
研究领域
相关产品
-
Compatible Secondaries
-
Conjugation kits
-
Isotype control
-
Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab91064于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
Flow Cyt |
Use 1µg for 106 cells.
Use 1µg for 106 cells in 100 µl total staining volume. ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
说明 |
---|
Flow Cyt
Use 1µg for 106 cells. Use 1µg for 106 cells in 100 µl total staining volume. ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
靶标
-
功能
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. -
组织特异性
Endothelial tissues and brain. -
序列相似性
Contains 5 cadherin domains. -
翻译后修饰
Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. -
细胞定位
Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries. - Information by UniProt
-
数据库链接
- Entrez Gene: 12562 Mouse
- SwissProt: P55284 Mouse
- Unigene: 21767 Mouse
-
别名
- 7B 4 antibody
- 7B4 antibody
- 7B4 antigen antibody
see all
图片
实验方案
数据表及文件
-
Datasheet download
文献 (8)
ab91064 被引用在 8 文献中.
- Li Z et al. Postnatal state transition of cardiomyocyte as a primary step in heart maturation. Protein Cell 13:842-862 (2022). PubMed: 35394262
- Jiang X et al. SOX7 suppresses endothelial-to-mesenchymal transitions by enhancing VE-cadherin expression during outflow tract development. Clin Sci (Lond) 135:829-846 (2021). PubMed: 33720353
- McDowell SAC et al. Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration. Nat Cancer 2:545-562 (2021). PubMed: 35122017
- Zhou X et al. Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing. ACS Nano 14:12732-12748 (2020). PubMed: 32931251
- Molinari F et al. The mitochondrial metabolic reprogramming agent trimetazidine as an 'exercise mimetic' in cachectic C26-bearing mice. J Cachexia Sarcopenia Muscle 8:954-973 (2017). PubMed: 29130633
- Giampietro C et al. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol 211:1177-92 (2015). PubMed: 26668327
- Herzog BH et al. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502:105-9 (2013). PubMed: 23995678
- Broermann A et al. Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo. J Exp Med 208:2393-401 (2011). WB, ICC/IF ; Mouse . PubMed: 22025303