Anti-VE Cadherin抗体[BV13] (ab91064)

概述

  • 产品名称Anti-VE Cadherin抗体[BV13]
    参阅全部 VE Cadherin 一抗
  • 描述
    大鼠单克隆抗体[BV13] to VE Cadherin
  • 经测试应用适用于: ICC/IF, WB, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Recombinant fragment corresponding to the extracellular domain of Mouse VE Cadherin.

  • 阳性对照
    • bEnd.3 cells

性能

应用

Our Abpromise guarantee covers the use of ab91064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration. PubMed: 22025303
WB Use at an assay dependent concentration. PubMed: 22025303
Flow Cyt Use 1µg for 106 cells.

Use 1µg for 106 cells in 100 µl total staining volume.

ab18407 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton.
  • 组织特异性Endothelial tissues and brain.
  • 序列相似性Contains 5 cadherin domains.
  • 翻译后修饰Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB.
  • 细胞定位Cell junction. Cell membrane. Found at cell-cell boundaries and probably at cell-matrix boundaries.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 7B 4 antibody
    • 7B4 antibody
    • 7B4 antigen antibody
    • CADH5_HUMAN antibody
    • Cadherin 5 antibody
    • Cadherin 5 type 2 antibody
    • Cadherin 5, type 2 (vascular endothelium) antibody
    • Cadherin 5, type 2, VE cadherin (vascular epithelium) antibody
    • cadherin, vascular endothelial antibody
    • cadherin, vascular endothelial, 1 antibody
    • Cadherin-5 antibody
    • Cadherin5 antibody
    • CD 144 antibody
    • CD144 antibody
    • CD144 antigen antibody
    • CDH 5 antibody
    • CDH5 antibody
    • CDH5 protein antibody
    • Endothelial specific cadherin antibody
    • FLJ17376 antibody
    • OTTHUMP00000174777 antibody
    • Vascular endothelial cadherin antibody
    • Vascular epithelium cadherin antibody
    • VE Cad antibody
    • VE-cadherin antibody
    • VEC antibody
    see all

Anti-VE Cadherin antibody [BV13] 图像

  • bEnd.3 cells were labelled with 0.5 µg Rat IgG1 isotype control antibody (open histogram) or 0.5 µg ab91064 (colored histogram) followed by Anti-Rat PE secondary antibody. Total viable cells were used for analysis.

Anti-VE Cadherin antibody [BV13] (ab91064)参考文献

This product has been referenced in:
  • Giampietro C  et al. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol 211:1177-92 (2015). Read more (PubMed: 26668327) »
  • Broermann A  et al. Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo. J Exp Med 208:2393-401 (2011). WB, ICC/IF ; Mouse . Read more (PubMed: 22025303) »

See all 2 Publications for this product

Product Wall

Application Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Sample Sheep Tissue sections (Spleen)
Antigen retrieval step Heat mediated - Buffer/Enzyme Used: EnVision FLEX Target Retrieval Solution
Permeabilization No
Specification Spleen
Fixative Formaldehyde
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提交于 Jul 18 2016

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