Anti-VDAC1/Porin抗体(ab76441)

概述

  • 产品名称Anti-VDAC1/Porin抗体
    参阅全部 VDAC1/Porin 一抗
  • 描述
    小鼠单克隆抗体to VDAC1/Porin
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment (GST-tag) corresponding to Human VDAC1/Porin aa 156-276.
    Sequence:

    NFETAKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETA VNLAWTAGNSNTRFGIAAKYQIDPDACFSAKVNNSSLIGLGYTQTLKPGI KLTLSALLDGKNVNAGGHKLG


    Database link: P21796

  • 阳性对照
    • immunogen

性能

应用

Our Abpromise guarantee covers the use of ab76441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明ELISA: Use at an assay dependent dilution.
    WB: 1/500 - 1/1000. Predicted molecular weight: 31 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
    • 组织特异性Heart, liver and skeletal muscle.
    • 序列相似性Belongs to the eukaryotic mitochondrial porin family.
    • 结构域Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
    • 细胞定位Mitochondrion outer membrane. Cell membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • N2441 antibody
      • OMP2 antibody
      • POR1 antibody
      • hVDAC1 antibody
      • MGC111064 antibody
      • Mitochondrial Porin antibody
      • Outer mitochondrial membrane protein porin 1 antibody
      • Plasmalemmal porin antibody
      • Porin 31HL antibody
      • Porin 31HM antibody
      • VDAC antibody
      • VDAC-1 antibody
      • Vdac1 antibody
      • VDAC1_HUMAN antibody
      • Voltage dependent anion channel 1 antibody
      • Voltage dependent anion selective channel protein 1 antibody
      • Voltage-dependent anion-selective channel protein 1 antibody
      • YNL055C antibody
      • YNL2441C antibody
      see all

    Anti-VDAC1/Porin antibody 图像

    • Anti-VDAC1/Porin antibody (ab76441) at 1/500 dilution + immunogen at 0.1 µg

      Secondary
      Goat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

      Predicted band size : 31 kDa
      Observed band size : 39 kDa (why is the actual band size different from the predicted?)

    Anti-VDAC1/Porin antibody (ab76441)参考文献

    ab76441 has not yet been referenced specifically in any publications.

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