Anti-VDAC1/Porin抗体[16G9E6BC4] - Mitochondrial Loading Control (ab110326)
Key features and details
- Mouse monoclonal [16G9E6BC4] to VDAC1/Porin - Mitochondrial Loading Control
- Suitable for: WB
- Reacts with: Saccharomyces cerevisiae
- Isotype: IgG1
概述
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产品名称
Anti-VDAC1/Porin抗体[16G9E6BC4] - Mitochondrial Loading Control
参阅全部 VDAC1/Porin 一抗 -
描述
小鼠单克隆抗体[16G9E6BC4] to VDAC1/Porin - Mitochondrial Loading Control -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Saccharomyces cerevisiae -
免疫原
Full length native protein (purified). This information is proprietary to Abcam and/or its suppliers.
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常规说明
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Product was previously marketed under the MitoSciences sub-brand.
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. Do Not Freeze. -
存储溶液
pH: 7.5
Preservative: 0.02% Sodium azide
Constituent: HEPES buffered saline -
Concentration information loading...
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纯度
IgG fraction -
纯化说明
ab110326 was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation. -
克隆
单克隆 -
克隆编号
16G9E6BC4 -
同种型
IgG1 -
轻链类型
kappa -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab110326于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB | (1) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa.
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说明 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 30 kDa. |
靶标
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功能
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. -
组织特异性
Heart, liver and skeletal muscle. -
序列相似性
Belongs to the eukaryotic mitochondrial porin family. -
结构域
Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity. -
细胞定位
Mitochondrion outer membrane. Cell membrane. - Information by UniProt
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数据库链接
- SwissProt: P04840 Saccharomyces cerevisiae
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别名
- N2441 antibody
- OMP2 antibody
- POR1 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (41)
ab110326 被引用在 41 文献中.
- Brettrager EJ et al. Sulfotransferase 4A1 activity facilitates sulfate-dependent cellular protection to oxidative stress. Sci Rep 12:1625 (2022). PubMed: 35102205
- Liu Y et al. Inokosterone from Gentiana rigescens Franch Extends the Longevity of Yeast and Mammalian Cells via Antioxidative Stress and Mitophagy Induction. Antioxidants (Basel) 11:N/A (2022). PubMed: 35204097
- Nývltová E et al. Coordination of metal center biogenesis in human cytochrome c oxidase. Nat Commun 13:3615 (2022). PubMed: 35750769
- Kemmerer ZA et al. UbiB proteins regulate cellular CoQ distribution in Saccharomyces cerevisiae. Nat Commun 12:4769 (2021). PubMed: 34362905
- Broeskamp F et al. Porin 1 Modulates Autophagy in Yeast. Cells 10:N/A (2021). PubMed: 34572064