Anti-VDAC1 / Porin抗体(ab119296)

概述

  • 产品名称Anti-VDAC1 / Porin抗体
    参阅全部 VDAC1 / Porin 一抗
  • 描述
    兔多克隆抗体to VDAC1 / Porin
  • 经测试应用适用于: WB, ELISA, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    NDGTEFGGSIYQK

    conjugated to KLH, corresponding to internal sequence amino acids 185-197 of Human VDAC1/ Porin.

  • 阳性对照
    • Human Liver tissue

性能

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应用

Our Abpromise guarantee covers the use of ab119296 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/2000. Predicted molecular weight: 31 kDa.
ELISA 1/10000 - 1/40000.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use at an assay dependent concentration.

靶标

  • 功能Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
  • 组织特异性Heart, liver and skeletal muscle.
  • 序列相似性Belongs to the eukaryotic mitochondrial porin family.
  • 结构域Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.
  • 细胞定位Mitochondrion outer membrane. Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hVDAC1 antibody
    • Outer mitochondrial membrane protein porin 1 antibody
    • Plasmalemmal porin antibody
    • Porin 31HL antibody
    • Porin 31HM antibody
    • Porin antibody
    • VDAC 1 antibody
    • VDAC antibody
    • VDAC-1 antibody
    • Vdac1 antibody
    • VDAC1_HUMAN antibody
    • Voltage Dependent Anion Channel 1 antibody
    • Voltage dependent anion selective channel protein 1 antibody
    • Voltage-dependent anion-selective channel protein 1 antibody
    see all

Anti-VDAC1 / Porin antibody 图像

  • ab119296 at 2.5 µg/ml staining VDAC1 / Porin in Human Liver by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Anti-VDAC1 / Porin antibody (ab119296)参考文献

ab119296 has not yet been referenced specifically in any publications.

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