概述

  • 产品名称Anti-VCAM1抗体[M/K-2] (FITC)
    参阅全部 VCAM1 一抗
  • 描述
    大鼠单克隆抗体[M/K-2] to VCAM1 (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 特异性This antibody is specific for VCAM1.
  • 经测试应用适用于: ICC/IF, IP, Functional Studies, Flow Cytmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    The details of the immunogen for this antibody are not available.

应用

Our Abpromise guarantee covers the use of ab24853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
Functional Studies Use at an assay dependent concentration.

Blockage of lymphocyte adhesion in Whitlock-Witte long-term bone marrow cultures and Inhibition of lymphopoiesis in Whitlock-Witte cultures.

Flow Cyt Use 1µg for 106 cells.

ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
  • 组织特异性Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
  • 序列相似性Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  • 结构域Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
  • 翻译后修饰Sialoglycoprotein.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CD106 antibody
    • CD106 Antigen antibody
    • INCAM 100 antibody
    • INCAM-100 antibody
    • L1CAM antibody
    • MGC99561 antibody
    • V-CAM 1 antibody
    • Vascular Cell Adhesion Molecule 1 antibody
    • Vascular cell adhesion protein 1 antibody
    • VCAM 1 antibody
    • VCAM-1 antibody
    • VCAM1 antibody
    • VCAM1_HUMAN antibody
    see all

Anti-VCAM1 antibody [M/K-2] (FITC) 图像

  • ab24853 staining mouse (Balb/c) bone marrow cells by flow cytometry. 1µg of antibody was used for 106 cells.

Anti-VCAM1 antibody [M/K-2] (FITC) (ab24853)参考文献

This product has been referenced in:
  • Zeng SL  et al. Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Mol Med Rep 12:2511-20 (2015). Read more (PubMed: 25936350) »
  • Acton SE  et al. Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature 514:498-502 (2014). Flow Cyt . Read more (PubMed: 25341788) »

See all 3 Publications for this product

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