功能Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
组织特异性Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue (1) and colon cancer tissue (2) using ab98954 at 1/200 dilution with DAB staining.
Anti-VCAM1 antibody [6G9] (ab98954)参考文献
This product has been referenced in:
Valero-Muñoz M et al. Relevance of vascular peroxisome proliferator-activated receptor ? coactivator-1a to molecular alterations in atherosclerosis. Exp Physiol98:999-1008 (2013).
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Rouault C et al. Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue. Endocrinology154:1069-79 (2013).
Read more (PubMed: 23372021) »