Anti-Vav蛋白抗体(ab92890)
Key features and details
- Rabbit polyclonal to Vav proteins
- Suitable for: WB, IP
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Vav蛋白抗体
参阅全部 Vav proteins 一抗 -
描述
兔多克隆抗体to Vav蛋白 -
宿主
Rabbit -
经测试应用
适用于: WB, IPmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide, corresponding to amino acids 172-176 of Human Vav proteins
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阳性对照
- Jurkat or THP1 cell lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab92890于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/1000. Predicted molecular weight: 98 kDa.
Predicted molecular weight: 98 kDa (VAV1 & VAV3). 101 kDa (VAV2). |
|
IP |
Use at an assay dependent concentration.
2 µg. |
说明 |
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WB
1/1000. Predicted molecular weight: 98 kDa. Predicted molecular weight: 98 kDa (VAV1 & VAV3). 101 kDa (VAV2). |
IP
Use at an assay dependent concentration. 2 µg. |
靶标
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相关性
The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav). First discovered based on its transforming properties, Vav is expressed mainly in hematopoietic cells and a few non-hematopoietic tissues, such as the pancreas and tooth enamels. As a signalling transducer, Vav is involved in T-cell activated transduction of T-cell antigen receptor (TCR). T-cell stimulated and tyrosine phosphorylated Vav acts as a catalyst in the exchange of guanosine nucleotides on Rac-1, a GTP binding protein. Using a mouse model, Vav expression has been determined to play an essential role in the cyctosketetal, proliferative, and apoptotic pathways for developing lymphoid cells and its signal response. -
细胞定位
Cytoplasmic and Plasma membrane VAV1, Cytoplasm - VAV2 & VAV3 -
数据库链接
- Entrez Gene: 10451 Human
- Entrez Gene: 7409 Human
- Entrez Gene: 7410 Human
- Omim: 164875 Human
- Omim: 600428 Human
- Omim: 605541 Human
- SwissProt: P15498 Human
- SwissProt: P52735 Human
see all -
别名
- 2810040F13Rik antibody
- A530094I06Rik antibody
- AA986410 antibody
see all
图片
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Immunoprecipitation of VAV proteins from 500µg of Jurkat (Lane 1) and THP1 (Lane 2) cell lysates, using 2µg of ab92890.
All lanes : Anti-Vav proteins antibody (ab92890) at 2 µg
Lane 1 : Jurkat cell lysate
Lane 2 : THP1 cell lysate
Lysates/proteins at 500 µg per lane. -
All lanes : Anti-Vav proteins antibody (ab92890) at 1/1000 dilution
Lane 1 : Jurkat cell lysate at 3 µg
Lane 2 : Jurkat cell lysate at 10 µg
Lane 3 : Jurkat cell lysate at 30 µg
Predicted band size: 98 kDa
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab92890 尚未被引用在任何文献中。