Anti-VAPB抗体(ab103638)
Key features and details
- Rabbit polyclonal to VAPB
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-VAPB抗体
参阅全部 VAPB 一抗 -
描述
兔多克隆抗体to VAPB -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Recombinant full length protein within Human VAPB. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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阳性对照
- Mouse lung tissue lysate; HepG2 cell lysate; VAPB transfected 293T cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab103638于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB | (2) |
1/500 - 1/1000. Predicted molecular weight: 27 kDa.
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说明 |
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WB
1/500 - 1/1000. Predicted molecular weight: 27 kDa. |
靶标
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功能
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. -
组织特异性
Ubiquitous. Isoform 1 predominates. -
疾病相关
Amyotrophic lateral sclerosis 8
Spinal muscular atrophy, proximal, adult, autosomal dominant -
序列相似性
Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.
Contains 1 MSP domain. -
细胞定位
Endoplasmic reticulum membrane. Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 9217 Human
- Entrez Gene: 56491 Mouse
- Omim: 605704 Human
- SwissProt: O95292 Human
- SwissProt: Q9QY76 Mouse
- Unigene: 182625 Human
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别名
- ALS 8 antibody
- ALS8 antibody
- D2Abb2e antibody
see all
图片
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Anti-VAPB antibody (ab103638) at 1/500 dilution + Mouse lung tissue lysate at 50 µg
Predicted band size: 27 kDa -
Anti-VAPB antibody (ab103638) at 1/500 dilution + HepG2 cell lysate at 50 µg
Predicted band size: 27 kDa -
All lanes : Anti-VAPB antibody (ab103638) at 1/500 dilution
Lane 1 : VAPB transfected 293T cell line lysate
Lane 2 : Non-transfected 293T cell line lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 27 kDa
数据表及文件
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Datasheet download
文献 (2)
ab103638 被引用在 2 文献中.
- Papadopoulou AA et al. Signal Peptide Peptidase-Like 2c (SPPL2c) impairs vesicular transport and cleavage of SNARE proteins. EMBO Rep 20:N/A (2019). PubMed: 30733281
- Papadopoulou AA et al. Signal peptide peptidase-like 2c impairs vesicular transport and cleaves SNARE proteins. EMBO Rep 20:e46451 (2019). PubMed: 32048434