概述

  • 产品名称Anti-VAP1抗体[7-88]
    参阅全部 VAP1 一抗
  • 描述
    大鼠单克隆抗体[7-88] to VAP1
  • 经测试应用适用于: IHC-Fr, Functional Studies, Flow Cyt, ICC/IF, IPmore details
  • 种属反应性
    与反应: Mouse
  • 免疫原

    Tissue/ cell preparation of vessels from Mouse lymph nodes

  • 阳性对照
    • Mouse spleen Mouse VAP-1-transfected CHO cells
  • 常规说明


    Inhibits migration of granulocytes and monocytes in acute models of inflammation.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab81673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/50.
Functional Studies Use at an assay dependent concentration. Antibody 7-88 (200µg) was intravenously injected which resulted in the inhibition of leukocyte trafficking in inflamed peritoneum.
Flow Cyt 1/50. ab18536-Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
ICC/IF 1/50.
IP Use at an assay dependent concentration.

靶标

  • 功能Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis.
  • 组织特异性Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis.
  • 序列相似性Belongs to the copper/topaquinone oxidase family.
  • 翻译后修饰Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
    N- and O-glycosylated.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Amine oxidase, copper containing 3 (vascular adhesion protein 1) antibody
    • AOC3 antibody
    • AOC3_HUMAN antibody
    • Copper amine oxidase antibody
    • HPAO antibody
    • Membrane copper amine oxidase antibody
    • Membrane primary amine oxidase antibody
    • Semicarbazide sensitive amine oxidase antibody
    • Semicarbazide-sensitive amine oxidase antibody
    • SSAO antibody
    • VAP-1 antibody
    • Vascular adhesion protein 1 antibody
    • VP97 antibody
    see all

Anti-VAP1 antibody [7-88] 图像

  • ab81673 staining VAP1 in mouse muscle tissue by Immunohistochemistry (Frozen sections).

Anti-VAP1 antibody [7-88] (ab81673)参考文献

This product has been referenced in:
  • Yoshikawa N  et al. Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization. Mol Vis 18:593-600 (2012). ICC/IF ; Mouse . Read more (PubMed: 22419852) »
  • Merinen M  et al. Vascular adhesion protein-1 is involved in both acute and chronic inflammation in the mouse. Am J Pathol 166:793-800 (2005). Flow Cyt, Functional Studies, IHC-Fr ; Mouse . Read more (PubMed: 15743791) »

See all 4 Publications for this product

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Thank you for having followed this up with the customer.

Indeed, the protocol seems to me to be intermediate in the fixation with paraffin embedded tissues, where the tissues are often fixed overnight in PFA, and with frozen sections, where t...

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