Valproic acid, sodium salt (ab120745)

概述

  • 产品名称Valproic acid, sodium salt
  • 描述
    Histone deacetylase inhibitor
  • 别名
    • 2-propylpentanoic acid sodium
    • Sodium 2-propylpentanoate
    • Sodium valproate
    • Valproate sodium
  • 生物学描述Histone deacetylase inhibitor (IC50 = 0.4 μM for HDAC1). Increases GABA expression and activates Wnt dependent gene expression. Centrally active upon oral and intravenous administration.

性能

    应用

    Our Abpromise guarantee covers the use of ab120745 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    Functional Studies Use at an assay dependent concentration.

    Valproic acid, sodium salt 图像

    • ab70362 staining adiponectin receptor 1 in HepG2 cells treated with valproic acid, sodium salt (ab120745), by ICC/IF. Increased cytoplasmatic staining of adiponectin receptor 1 correlates with increased concentration of valproic acid, as described in literature. The cells were incubated at 37°C for 24h in media containing different concentrations of ab120745 (valproic acid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab70362 (5 μg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Valproic acid, sodium salt (ab120745)参考文献

    This product has been referenced in:
    • De Sarno P  et al. Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium. Neuropharmacology 43:1158-64 (2002). Read more (PubMed: 12504922) »
    • Phiel CJ  et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276:36734-41 (2001). Read more (PubMed: 11473107) »
    • Keane PE  et al. The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice. Neuropharmacology 22:875-9 (1983). Read more (PubMed: 6413882) »

    See 0 Publications for this product

    Product Wall

    Unfortunately, we do not conduct scientific research within our labs and so we do not test the specific actions of our inhibitors. We simply produce this biochemical to a high quality.

    I would suggest that your customer looks at the available...

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    Thank you for contacting us.

    Yes, I can confirm that the ab40988 is able to recognize free valproic acid, therefore the ab120745. The laboratory confirmed indeed that this antibody has been used in a competitive immunoassay in which antibody...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"