Anti-Valproic Acid抗体[10-115.2] (ab40986)

概述

  • 产品名称Anti-Valproic Acid抗体[10-115.2]
    参阅全部 Valproic Acid 一抗
  • 描述
    小鼠单克隆抗体[10-115.2] to Valproic Acid
  • 经测试应用适用于: Indirect ELISAmore details
  • 免疫原

    Valproic acid conjugated to KLH.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号10-115.2
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab40986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Indirect ELISA
  • 应用说明I-ELISA: 1/51200 end point titre. Valproic acid conjugated to BSA on the solid phase.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Valproic acid, valproate sodium and divalproex belong to the group of medicines called anticonvulsants, used to control certain types of seizures in the treatment of epilepsy. Also, valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic centre of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed haematopoietic progenitor cells and leukaemic blasts from acute myeloid leukaemia patients. Moreover, tumour growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.
    • 别名
      • 2methylbutyryl coa dehydrogenase antibody
      • 2methylbutyryl coenzyme a dehydrogenase antibody

    Anti-Valproic Acid antibody [10-115.2] (ab40986)参考文献

    ab40986 has not yet been referenced specifically in any publications.

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