Valinomycin from Streptomyces fulvissimus (ab120852)

概述

  • 产品名称Valinomycin from Streptomyces fulvissimus
  • 描述
    K+ selective ionophore
  • 生物学描述K+ selective ionophore. Natural dodecadepsipeptide. Antitumor, antifungal and antibacterial effects. Apoptosis due to caspase independent mechanisms.
  • 纯度> 98%

性能

    应用

    Our Abpromise guarantee covers the use of ab120852 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    Functional Studies Use at an assay dependent concentration.

    Valinomycin from Streptomyces fulvissimus 图像

    • ab56889 staining mitodusin2 in MEF1 cells treated with valinomycin from Streptomyces fulvissimus (ab120852), by ICC/IF. Decrease in mitofusin2 expression with increased concentration of withaferin valinomycin from Streptomyces fulvissimus, as described in literature.
      The cells were incubated at 37°C for 3h in media containing different concentrations of ab120852 (valinomycin from Streptomyces fulvissimus) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab56889 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    Valinomycin from Streptomyces fulvissimus (ab120852)参考文献

    This product has been referenced in:
    • Kroten MA  et al. Cereulide and valinomycin, two important natural dodecadepsipeptides with ionophoretic activities. Pol J Microbiol 59:3-10 (2010). Read more (PubMed: 20568524) »
    • Yamada A  et al. Differential permeabilization effects of Ca2+ and valinomycin on the inner and outer mitochondrial membranes as revealed by proteomics analysis of proteins released from mitochondria. Mol Cell Proteomics 8:1265-77 (2009). Read more (PubMed: 19218587) »
    • Duax WL  et al. Molecular structure and mechanisms of action of cyclic and linear ion transport antibiotics. Biopolymers 40:141-55 (1996). Read more (PubMed: 8541445) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120852.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"