概述

  • 产品名称Anti-Vaccinia Virus抗体(FITC)
    参阅全部 Vaccinia Virus 一抗
  • 描述
    兔多克隆抗体to Vaccinia Virus (FITC)
  • 偶联物FITC. Ex: 493nm, Em: 528nm
  • 特异性Ab19970 recognizes purified virions.
  • 经测试应用适用于: ICC/IFmore details
  • 种属反应性
    Ab19970 is reactive with Lister, Wyeth, New York City and MVA strains of Vaccinia. Does not react with Parainfluenza (1-3), RSV, Adenovirus, Influenza A&B or HSV-1 or with uninfected cells.
  • 免疫原

    Lister strain (mixture of virions and infected cell polypeptides)

  • 常规说明

    IgG fraction covalently coupled with high purity Isomer I of fluorescein isothiocyanate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: 10mg/ml BSA, 10mM PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 纯化说明Care is taken to ensure complete removal of any free fluorescein from the final product.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab19970 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent dilution.

靶标

  • 相关性Vaccinia virus is an Orthopoxvirus, containing double stranded DNA. Fusion protein plays an important role in the entry of enveloped virus into cells. As vaccinia virus has a wide host range, it is conceivable that certain cellular components that are ubiquitously expressed on the cell mediate virus infection. The study of the entry process, attachment, fusion and the proteins and receptors involved is complex. During vaccinia virus infection, the fusion process is attributed to the action of the 14KDa protein (A27L). The N terminus of this protein recognises heparan sulfate on the cell surface. It interacts with the negative charges of sulfates of glycosaminoglycans (GAGs). Therefore, antibodies that recognize this 14KDa protein are able to neutralize vaccinia virus infection and enable identification other viral and cellular proteins which participate in the vaccinia virus entry process.
  • 别名
    • A27L antibody
    • Orthopoxvirus antibody

Anti-Vaccinia Virus antibody (FITC) (ab19970)参考文献

This product has been referenced in:
  • Hou W  et al. Oncolytic vaccinia virus demonstrates antiangiogenic effects mediated by targeting of VEGF. Int J Cancer 135:1238-46 (2014). Read more (PubMed: 24474587) »
  • Li Z  et al. A flow cytometry-based immuno-titration assay for rapid and accurate titer determination of modified vaccinia Ankara virus vectors. J Virol Methods 169:87-94 (2010). Read more (PubMed: 20637240) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"