概述

  • 产品名称Anti-USP5抗体
    参阅全部 USP5 一抗
  • 描述
    小鼠单克隆抗体to USP5
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment, corresponding to amino acids 71-181 of Human USP5

性能

应用

Our Abpromise guarantee covers the use of ab56372 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
    • 序列相似性Belongs to the peptidase C19 family.
      Contains 2 UBA domains.
      Contains 1 UBP-type zinc finger.
    • 结构域The UBP-type zinc finger domain interacts selectively with an unmodified C-terminus of the proximal ubiquitin. Both UBA domains are involved in polyubiquitin recognition.
    • 翻译后修饰The N-terminus is blocked.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Deubiquitinating enzyme 5 antibody
      • Isopeptidase T antibody
      • ISOT 1 antibody
      • ISOT antibody
      • Ubiquitin carboxyl-terminal hydrolase 5 antibody
      • Ubiquitin isopeptidase T antibody
      • Ubiquitin specific peptidase 5 (isopeptidase T) antibody
      • Ubiquitin specific peptidase 5 antibody
      • Ubiquitin specific processing protease 5 antibody
      • Ubiquitin specific protease 5 (isopeptidase T) antibody
      • Ubiquitin specific protease 5 (ubiquitin isopeptidase T) antibody
      • Ubiquitin thioesterase 5 antibody
      • Ubiquitin thiolesterase 5 antibody
      • Ubiquitin-specific-processing protease 5 antibody
      • UBP5_HUMAN antibody
      • Usp5 antibody
      see all

    Anti-USP5 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56372 USP5 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    Anti-USP5 antibody (ab56372)参考文献

    ab56372 has not yet been referenced specifically in any publications.

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