概述

  • 产品名称Anti-USP4抗体
    参阅全部 USP4 一抗
  • 描述
    兔多克隆抗体to USP4
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan, Bat
  • 免疫原

    Synthetic peptide corresponding to a region between residue 225 and 275 of human USP4

  • 阳性对照
    • HeLa whole cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab70617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP
  • 应用说明IP: Use at 2-5µg/mg of lysate.

    Is unsuitable for WB.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER.
    • 组织特异性Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons.
    • 序列相似性Belongs to the peptidase C19 family. USP4 subfamily.
      Contains 1 DUSP domain.
    • 翻译后修饰Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated.
    • 细胞定位Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Deubiquitinating enzyme 4 antibody
      • MGC149848 antibody
      • MGC149849 antibody
      • Proto oncogene antibody
      • Protooncogene antibody
      • Ubiquitin carboxyl terminal hydrolase 4 antibody
      • Ubiquitin carboxyl-terminal hydrolase 4 antibody
      • Ubiquitin specific peptidase 4 (proto oncogene) antibody
      • Ubiquitin specific peptidase 4 (protooncogene) antibody
      • Ubiquitin specific peptidase 4 antibody
      • Ubiquitin specific processing protease 4 antibody
      • Ubiquitin specific protease 4 (proto oncogene) antibody
      • Ubiquitin specific protease 4 (protooncogene) antibody
      • Ubiquitin specific protease 4 antibody
      • Ubiquitin specific protease proto oncogene antibody
      • Ubiquitin specific protease protooncogene antibody
      • Ubiquitin thioesterase 4 antibody
      • Ubiquitin thiolesterase 4 antibody
      • Ubiquitin-specific-processing protease 4 antibody
      • Ubiquitous nuclear protein homolog antibody
      • UBP4_HUMAN antibody
      • UNP antibody
      • UNPH antibody
      • USP 4 antibody
      • USP4 antibody
      see all

    Anti-USP4 antibody 图像

    • Detection of Human USP4 by Western Blot of Immunprecipitate. ab70617 at 1µg/ml staining USP4 (approximately 120kDa) in HeLa whole cell lysates immunoprecipitated using ab70617 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).Detection: Chemiluminescence with an exposure time of 30 seconds.

    Anti-USP4 antibody (ab70617)参考文献

    ab70617 has not yet been referenced specifically in any publications.

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