概述

  • 产品名称Anti-USP4抗体
    参阅全部 USP4 一抗
  • 描述
    兔多克隆抗体to USP4
  • 经测试应用适用于: ELISA, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to C terminal of USP4 and derived from within residues 914-963 (Human)

  • 阳性对照
    • USP4-transfected HeLa cell lysate, Human hepatocarcinoma

性能

应用

Our Abpromise guarantee covers the use of ab38510 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Predicted molecular weight: 108 kDa.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. Plays a role in the regulation of quality control in the ER.
  • 组织特异性Overexpressed in small cell tumors and adenocarcinomas of the lung compared to wild-type lung (at protein level). Expressed in the hippocampal neurons.
  • 序列相似性Belongs to the peptidase C19 family. USP4 subfamily.
    Contains 1 DUSP domain.
  • 翻译后修饰Monoubiquitinated by TRIM21. Ubiquitination does not lead to its proteasomal degradation. Autodeubiquitinated.
  • 细胞定位Cytoplasm. Nucleus. Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Deubiquitinating enzyme 4 antibody
    • MGC149848 antibody
    • MGC149849 antibody
    • Proto oncogene antibody
    • Protooncogene antibody
    • Ubiquitin carboxyl terminal hydrolase 4 antibody
    • Ubiquitin carboxyl-terminal hydrolase 4 antibody
    • Ubiquitin specific peptidase 4 (proto oncogene) antibody
    • Ubiquitin specific peptidase 4 (protooncogene) antibody
    • Ubiquitin specific peptidase 4 antibody
    • Ubiquitin specific processing protease 4 antibody
    • Ubiquitin specific protease 4 (proto oncogene) antibody
    • Ubiquitin specific protease 4 (protooncogene) antibody
    • Ubiquitin specific protease 4 antibody
    • Ubiquitin specific protease proto oncogene antibody
    • Ubiquitin specific protease protooncogene antibody
    • Ubiquitin thioesterase 4 antibody
    • Ubiquitin thiolesterase 4 antibody
    • Ubiquitin-specific-processing protease 4 antibody
    • Ubiquitous nuclear protein homolog antibody
    • UBP4_HUMAN antibody
    • UNP antibody
    • UNPH antibody
    • USP 4 antibody
    • USP4 antibody
    see all

Anti-USP4 antibody 图像

  • Anti-USP4 antibody (ab38510) + USP4-transfected HeLa cell lysate

    Predicted band size : 108 kDa
    Observed band size : 110 kDa (why is the actual band size different from the predicted?)
  • Ab38510 staining Human hepatocarcinoma; formalin fixed, paraffin embedded. Ab38510 was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

Anti-USP4 antibody (ab38510)参考文献

ab38510 has not yet been referenced specifically in any publications.

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