概述

  • 产品名称Anti-USP34抗体
    参阅全部 USP34 一抗
  • 描述
    兔多克隆抗体to USP34
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Chinese Hamster, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residue 3350 and the C-terminus (residue 3395) of Human USP34 (CAE51938.1).

  • 阳性对照
    • Human breast carcinoma and prostate carcinoma tissue

性能

应用

Our Abpromise guarantee covers the use of ab91617 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with Tris-EDTA pH9.0 buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins.
    • 组织特异性Expressed in brain at low level.
    • 序列相似性Belongs to the peptidase C19 family.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Deubiquitinating enzyme 34 antibody
      • FLJ43910 antibody
      • KIAA0570 antibody
      • KIAA0729 antibody
      • MGC104459 antibody
      • Ubiquitin carboxyl terminal hydrolase 34 antibody
      • Ubiquitin carboxyl-terminal hydrolase 34 antibody
      • Ubiquitin specific processing protease 34 antibody
      • Ubiquitin specific protease 34 antibody
      • Ubiquitin thioesterase 34 antibody
      • Ubiquitin thiolesterase 34 antibody
      • Ubiquitin-specific-processing protease 34 antibody
      • UBP34_HUMAN antibody
      • USP 34 antibody
      • Usp34 antibody
      see all

    Anti-USP34 antibody 图像

    • ab91617, at 1/250 dilution, staining USP34 in formalin-fixed paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry using DAB staining.
    • ab91617, at 1/250 dilution, staining USP34 in formalin-fixed paraffin-embedded Human prostate carcinoma tissue by Immunohistochemistry using DAB staining.

    Anti-USP34 antibody (ab91617)参考文献

    ab91617 has not yet been referenced specifically in any publications.

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