概述

  • 产品名称
  • 描述
    兔多克隆抗体to USP3
  • 经测试应用
    适用于: IHC-P, IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide (Human) mapped to a region between residues 471 and 521

  • 阳性对照
    • HeLa whole cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab80597 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1000 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
IP Use a concentration of 2 - 5 µg/ml.
  • 应用说明
    Is unsuitable for WB.
  • 靶标

    • 功能
      Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
    • 组织特异性
      Expressed in all tissues examined, with strongest expression in pancreas.
    • 序列相似性
      Belongs to the peptidase C19 family. USP3 subfamily.
      Contains 1 UBP-type zinc finger.
    • 结构域
      Both protease activity and an intact zinc finger are required for H2A monodeubiquitination.
    • 细胞定位
      Nucleus. Localizes preferentially with monoubiquitinated H2A to chromatin.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Deubiquitinating enzyme 3 antibody
      • EC 3.1.2.15 antibody
      • SIH003 antibody
      • Ubiquitin carboxyl-terminal hydrolase 3 antibody
      • Ubiquitin specific peptidase 3 antibody
      • Ubiquitin specific processing protease 3 antibody
      • Ubiquitin Specific Protease 3 antibody
      • Ubiquitin thioesterase 3 antibody
      • Ubiquitin thiolesterase 3 antibody
      • Ubiquitin-specific-processing protease 3 antibody
      • UBP antibody
      • UBP3_HUMAN antibody
      • Usp3 antibody
      see all

    图片

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling USP3 with ab80597 at 1/1000 (1µg/ml). Detection: DAB.

    文献

    ab80597 has not yet been referenced specifically in any publications.

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