Anti-USP2抗体- Aminoterminal end (ab71796)

概述

  • 产品名称Anti-USP2抗体- Aminoterminal end
    参阅全部 USP2 一抗
  • 描述
    兔多克隆抗体to USP2 - Aminoterminal end
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A KLH conjugated synthetic peptide selected from the N-terminal region of human USP2.

  • 阳性对照
    • HL60 cell lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab71796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/1000.
    WB: 1/100 - 1/500. Detects a band of approximately 68 kDa plus a range of other bands. (predicted molecular weight: 68 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.
    • 组织特异性Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).
    • 序列相似性Belongs to the peptidase C19 family. USP2 subfamily.
    • 结构域The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
    • 细胞定位Nucleus and Cytoplasm. Cytoplasm > perinuclear region. Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 41 kDa ubiquitin specific protease antibody
      • 41 kDa ubiquitin-specific protease antibody
      • Deubiquitinating enzyme 2 antibody
      • Ubiquitin carboxyl terminal hydrolase 2 antibody
      • Ubiquitin carboxyl-terminal hydrolase 2 antibody
      • ubiquitin specific peptidase 2 antibody
      • Ubiquitin specific processing protease 2 antibody
      • Ubiquitin specific protease 12 antibody
      • Ubiquitin specific protease 9 antibody
      • Ubiquitin specific protease, 41kD antibody
      • Ubiquitin thioesterase 2 antibody
      • Ubiquitin thiolesterase 2 antibody
      • Ubiquitin-specific-processing protease 2 antibody
      • Ubiquitin-specific-processing protease testis antibody
      • UBP-t antibody
      • UBP2_HUMAN antibody
      • UBP41 antibody
      • USP2 antibody
      • USP9 antibody
      see all

    Anti-USP2 antibody - Aminoterminal end 图像

    • Anti-USP2 antibody - Aminoterminal end (ab71796) at 1/100 dilution + HL60 cell lysate at 12.5 µg

      Predicted band size : 68 kDa
      Observed band size : 68 kDa

    Anti-USP2 antibody - Aminoterminal end (ab71796)参考文献

    ab71796 has not yet been referenced specifically in any publications.

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    ab71796, Anti-USP2 antibody - Aminoterminal end antibody detect the N-terminal of USP2. It detects USP2 isoform a (USP2a) only but not USP2b.

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