概述

  • 产品名称Anti-USP2抗体
    参阅全部 USP2 一抗
  • 描述
    兔多克隆抗体to USP2
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide from an internal sequence of Human USP2, conjugated to KLH.

  • 阳性对照
    • Human skeletal muscle tissue.

性能

应用

Our Abpromise guarantee covers the use of ab62047 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 1.3 µg/ml.

靶标

  • 功能Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.
  • 组织特异性Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level).
  • 序列相似性Belongs to the peptidase C19 family. USP2 subfamily.
  • 结构域The different N-terminus extensions of isoform 1 and isoform 4 determine their respective subcellular localization and differentiel effect on myoblast fusion and accumulation of muscle-specific proteins. The different N-terminus extensions of isoform 1 and isoform 4 are not essential for their catalytic activity.
  • 细胞定位Nucleus and Cytoplasm. Cytoplasm > perinuclear region. Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 41 kDa ubiquitin specific protease antibody
    • 41 kDa ubiquitin-specific protease antibody
    • Deubiquitinating enzyme 2 antibody
    • Ubiquitin carboxyl terminal hydrolase 2 antibody
    • Ubiquitin carboxyl-terminal hydrolase 2 antibody
    • ubiquitin specific peptidase 2 antibody
    • Ubiquitin specific processing protease 2 antibody
    • Ubiquitin specific protease 12 antibody
    • Ubiquitin specific protease 9 antibody
    • Ubiquitin specific protease, 41kD antibody
    • Ubiquitin thioesterase 2 antibody
    • Ubiquitin thiolesterase 2 antibody
    • Ubiquitin-specific-processing protease 2 antibody
    • Ubiquitin-specific-processing protease testis antibody
    • UBP-t antibody
    • UBP2_HUMAN antibody
    • UBP41 antibody
    • USP2 antibody
    • USP9 antibody
    see all

Anti-USP2 antibody 图像

  • ab62047 at 1.3µg/ml staining USP2 in human skeletal muscle by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

Anti-USP2 antibody (ab62047)参考文献

ab62047 has not yet been referenced specifically in any publications.

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