Anti-USP19抗体(ab68527)
Key features and details
- Mouse polyclonal to USP19
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-USP19抗体
参阅全部 USP19 一抗 -
描述
小鼠多克隆抗体to USP19 -
宿主
Mouse -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human -
免疫原
Full-length Human protein (NP_006668.1, aa 1-1318).
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阳性对照
- USP19-transfected 293T cells lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.4
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab68527于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/1000. Detects a band of approximately 175 kDa (predicted molecular weight: 145 kDa).
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说明 |
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WB
1/500 - 1/1000. Detects a band of approximately 175 kDa (predicted molecular weight: 145 kDa). |
靶标
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功能
Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. -
序列相似性
Belongs to the peptidase C19 family.
Contains 2 CS domains.
Contains 1 MYND-type zinc finger. -
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. -
细胞定位
Endoplasmic reticulum membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 10869 Human
- Omim: 614471 Human
- SwissProt: O94966 Human
- Unigene: 255596 Human
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别名
- 8430421I07Rik antibody
- AI047774 antibody
- Deubiquitinating enzyme 19 antibody
see all
图片
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All lanes : Anti-USP19 antibody (ab68527) at 1/500 dilution
Lane 1 : transfected 293T cell lysate
Lane 2 : non transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution
Predicted band size: 145 kDa
Observed band size: 175 kDa why is the actual band size different from the predicted?
数据表及文件
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Datasheet download
文献 (2)
ab68527 被引用在 2 文献中.
- Zhang A et al. USP33 deubiquitinates and stabilizes HIF-2alpha to promote hypoxia response in glioma stem cells. EMBO J 41:e109187 (2022). PubMed: 35191554
- Bernadotte A et al. In silico identification and biochemical characterization of the human dicarboxylate clamp TPR protein interaction network. FEBS Open Bio 8:1830-1843 (2018). PubMed: 30410862