概述

  • 产品名称
  • 描述
    兔多克隆抗体to USP15
  • 经测试应用
    适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 941-952 of Human USP15 (NP_006304).

  • 阳性对照
    • WB: 293T, A431, H1299, HeLa, MOLT4 and Raji cell lines IHC-P: N87 xenograft

性能

应用

Our Abpromise guarantee covers the use of ab97533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 112 kDa.
IHC-P 1/100 - 1/250.
ICC/IF 1/100 - 1/200.

靶标

  • 功能
    Protease that degrades 'Lys-48'-linked polyubiquitin chains. Protects target proteins against proteasomal degradation. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
  • 组织特异性
    Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.
  • 序列相似性
    Belongs to the peptidase C19 family.
    Contains 1 DUSP domain.
  • 翻译后修饰
    Phosphorylated. Phosphorylation protects against ubiquitination and subsequent degradation by the proteasome.
    Ubiquitinated, leading to degradation by the proteasome.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Deubiquitinating enzyme 15 antibody
    • Deubiquitinating enzyme antibody
    • EC 3 1 2 15 antibody
    • KIAA0529 antibody
    • MGC131982 antibody
    • MGC149838 antibody
    • MGC74854 antibody
    • Ubiquitin Carboxy terminal Hydrolase 15 antibody
    • Ubiquitin carboxyl-terminal hydrolase 15 antibody
    • Ubiquitin specific peptidase 15 antibody
    • Ubiquitin specific processing protease 15 antibody
    • Ubiquitin Specific Protease 15 antibody
    • Ubiquitin thioesterase 15 antibody
    • Ubiquitin thiolesterase 15 antibody
    • Ubiquitin-specific-processing protease 15 antibody
    • UBP 15 antibody
    • UBP15 antibody
    • UBP15_HUMAN antibody
    • Unph 2 antibody
    • UNPH 4 antibody
    • Unph-2 antibody
    • Unph2 antibody
    • Unph4 antibody
    • USP 15 antibody
    • Usp15 antibody
    see all

图片

  • Immunofluorescence analysis of paraformaldehyde-fixed A431, using USP15(GTX104644) antibody at 1:200 dilution.
  • Anti-USP15 antibody (ab97533) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 112 kDa
  • Immunohistochemical analysis of USP15 in paraffin embedded N87 xenograft, using ab97533 at a 1/100 dilution.

文献

This product has been referenced in:
  • Eichhorn PJ  et al. USP15 stabilizes TGF-ß receptor I and promotes oncogenesis through the activation of TGF-ß signaling in glioblastoma. Nat Med 18:429-35 (2012). Read more (PubMed: 22344298) »

See 1 Publication for this product

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