概述

  • 产品名称Anti-USP10抗体
    参阅全部 USP10 一抗
  • 描述
    兔多克隆抗体to USP10
  • 经测试应用适用于: ICC, WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to N terminal residues of Human USP10 (CAB82392.2).

  • 阳性对照
    • Human brain (cortex), colon and breast tissues.

性能

应用

Our Abpromise guarantee covers the use of ab117606 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 87 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the peptidase C19 family. USP10 subfamily.
  • 翻译后修饰Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus.
  • 细胞定位Cytoplasm. Nucleus. Early endosome. Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Deubiquitinating enzyme 10 antibody
    • KIAA0190 antibody
    • MGC124997 antibody
    • MGC2621 antibody
    • Ubiquitin carboxyl terminal hydrolase 10 antibody
    • Ubiquitin carboxyl-terminal hydrolase 10 antibody
    • Ubiquitin specific peptidase 10 antibody
    • Ubiquitin specific processing protease 10 antibody
    • Ubiquitin specific protease 10 antibody
    • Ubiquitin thioesterase 10 antibody
    • Ubiquitin thiolesterase 10 antibody
    • Ubiquitin-specific-processing protease 10 antibody
    • UBP10_HUMAN antibody
    • UBPO antibody
    • USP 10 antibody
    • USP10 antibody
    see all

Anti-USP10 antibody 图像

  • ab117606, at 5 µg/ml, staining USP10 in Formalin-fixed, Paraffin-embedded Human Brain (cortex) tissue by Immunohistochemistry.
  • ab117606, at 5 µg/ml, staining USP10 in Formalin-fixed, Paraffin-embedded Human Breast tissue by Immunohistochemistry.
  • ab117606, at 5 µg/ml, staining USP10 in Formalin-fixed, Paraffin-embedded Human Colon tissue by Immunohistochemistry.

Anti-USP10 antibody (ab117606)参考文献

ab117606 has not yet been referenced specifically in any publications.

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