概述

  • 产品名称Anti-USP1抗体
    参阅全部 USP1 一抗
  • 描述
    兔多克隆抗体to USP1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residue 450 and 500 of human USP1 (NP_003359.3)

  • 阳性对照
    • Human controls: Anaplastic Thyroid Carcinoma, Breast Carcinoma, Prostate Carcinoma, Small Cell Lung Cancer

性能

应用

Our Abpromise guarantee covers the use of ab84772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure is recommended.
    Epitope exposure with citrate or tris-EDTA pH9.0 buffer will enhance staining.

    Likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
    • 序列相似性Belongs to the peptidase C19 family.
    • 发展阶段Cell cycle-regulated. Highest level during S phase.
    • 翻译后修饰Autocatalytic cleavage of USP1 following UV irradiation inactivates it leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
      Ubiquitinated; leading to its subsequent proteasomal degradation.
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Deubiquitinating enzyme 1 antibody
      • hUBP antibody
      • Ubiquitin carboxyl terminal hydrolase 1 antibody
      • Ubiquitin carboxyl-terminal hydrolase 1 antibody
      • Ubiquitin specific peptidase 1 antibody
      • Ubiquitin specific protease 1 antibody
      • Ubiquitin thioesterase 1 antibody
      • Ubiquitin thiolesterase 1 antibody
      • Ubiquitin-specific-processing protease 1 antibody
      • UBP antibody
      • UBP1_HUMAN antibody
      • USP 1 antibody
      • Usp1 antibody
      see all

    Anti-USP1 antibody 图像

    • Staining of USP1 by Immunohistochemistry on a formalin fixed, paraffin embedded section of human thyroid carcinoma using a 1/250 dilution of ab84772. Detection: DAB staining

    Anti-USP1 antibody (ab84772)参考文献

    ab84772 has not yet been referenced specifically in any publications.

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