概述

  • 产品名称Anti-URP2抗体
    参阅全部 URP2 一抗
  • 描述
    山羊多克隆抗体to URP2
  • 特异性ab106741 is expected to recognize both isoforms (NP_113659.3, NP_848537.1).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-ERARGEELDED

    , corresponding to C terminal amino acids 645-655 of Human URP2 (NP_848537.1).

  • 阳性对照
    • Human Peripheral Blood Mononucleocytes lysates.

性能

应用

Our Abpromise guarantee covers the use of ab106741 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 76 kDa.

靶标

  • 功能Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs).
    Isoform 2 may act as a repressor of NF-kappa-B and apoptosis.
  • 组织特异性Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.
  • 疾病相关Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3) [MIM:612840]; also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes.
  • 序列相似性Belongs to the kindlin family.
    Contains 1 FERM domain.
    Contains 1 PH domain.
  • 结构域The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
  • 细胞定位Cell projection > podosome. Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Fermitin family homolog 3 antibody
    • Fermitin family member 3 antibody
    • FERMT3 antibody
    • Kind3 antibody
    • Kindlin 3 antibody
    • Kindlin-3 antibody
    • Kindlin3 antibody
    • MGC10966 antibody
    • MIG 2 antibody
    • MIG2 like protein antibody
    • MIG2-like protein antibody
    • MIG2B antibody
    • Unc 112 related protein 2 antibody
    • Unc-112-related protein 2 antibody
    • UNC112C antibody
    • URP2_HUMAN antibody
    • URP2SF antibody
    see all

Anti-URP2 antibody 图像

  • Anti-URP2 antibody (ab106741) at 1 µg/ml + Human Peripheral Blood Mononucleocytes lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 76 kDa

Anti-URP2 antibody (ab106741)参考文献

ab106741 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab106741.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"