概述

  • 产品名称Anti-Uroplakin III抗体
    参阅全部 Uroplakin III 一抗
  • 描述
    兔多克隆抗体to Uroplakin III
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human Uroplakin III (C terminal).

  • 阳性对照
    • Human Bladder

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.1% Sodium Azide
    Constituents: 1% BSA, 10mM PBS, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab82173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB Use at an assay dependent concentration.

靶标

  • 功能Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.
  • 组织特异性Expressed in ureter.
  • 疾病相关Defects in UPK3A are a cause of renal adysplasia (RADYS) [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.
  • 序列相似性Belongs to the uroplakin-3 family.
  • 细胞定位Endoplasmic reticulum membrane. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).
  • Information by UniProt
  • 数据库链接
  • 别名
    • MGC119178 antibody
    • OTTHUMP00000028951 antibody
    • UP III antibody
    • UP3a antibody
    • UPIII antibody
    • UPIIIA antibody
    • UPK 3 antibody
    • UPK 3A antibody
    • UPK3 antibody
    • UPK3A antibody
    • UPK3A_HUMAN antibody
    • Uroplakin 3A antibody
    • Uroplakin III antibody
    • Uroplakin-3a antibody
    • Uroplakin3A antibody
    • UroplakinIII antibody
    see all

Anti-Uroplakin III antibody 图像

  • Formalin-fixed, paraffin-embedded section of Human bladder stained with ab82173 at 1/100 dilution. Incubate primary antibody (ab82173) for 10 minutes at RT.
  • Anti-Uroplakin III antibody (ab82173) at 1/100 dilution + lysate prepared from bladder

Anti-Uroplakin III antibody (ab82173)参考文献

This product has been referenced in:
  • Hou T  et al. Aberrant differentiation of urothelial cells in patients with ureteropelvic junction obstruction. Int J Clin Exp Pathol 7:5837-45 (2014). IF ; Human . Read more (PubMed: 25337225) »
  • Hicks AN  et al. Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): Consequences for mouse bladder development and function. Neurourol Urodyn : (2013). Read more (PubMed: 23371862) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab82173.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"