概述

  • 产品名称Anti-Uromucoid抗体
    参阅全部 Uromucoid 一抗
  • 描述
    羊多克隆抗体to Uromucoid
  • 特异性This product has been shown to be specific by gel diffusion techniques.
  • 经测试应用适用于: Double Immunodiffusion, RID, Immunoelectrophoresismore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human Uromucoid purified from human urine. Greater than 95% purity by SDS-PAGE.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Glycine buffered saline pH7.4, 0.1% Sodium Azide, 0.1% EACA, 0.01% Benzamidine,1mM EDTA
  • Concentration information loading...
  • 纯度IgG fraction
  • 纯化说明Antiserum is prepared by immunisation of sheep with Human Uromucoid and, if necessary, adsorbed to monospecificity by use of solid-phase adsorbents. An immunoglobulin fraction is then produced. The titre is adjusted so that inter-batch variation is within 10%. The product is 0.2µm filtered.
  • 克隆多克隆
  • 同种型IgG
  • 轻链类型unknown
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab9029 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Double Immunodiffusion
RID
Immunoelectrophoresis
Rocket Immunoelectrophoresis
  • 应用说明RID and Rocket IEP : 10µL antiserum/cm² in gel vs 5µL uromucoid 50mg/L, NT – 1/5
    Double Diffusion : 10µL antiserum vs 3µL uromucoid 50mg/L
    IEP : 100µL antiserum vs 5µL uromucoid 50mg/L

    Optimal dilutions should be determined by the individual laboratory
    The use of 3% PEG 6000 with 1.2%agarose in a suitable buffer (such as TBE or Tris-barbital pH >8.2) is recommended.
    Suitability for use in enzyme-linked immunosorbentassays and Western blot has not been assessed but use in such assays should not necessarily beexcluded.
  • 靶标

    • 功能Not known. May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
    • 组织特异性Synthesized by kidney. Most abundant protein in normal human urine.
    • 疾病相关Defects in UMOD are the cause of familial juvenile hyperuricemic nephropathy type 1 (HNFJ1) [MIM:162000]. HNFJ1 is a renal disease characterized by juvenil onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.
      Defects in UMOD are the cause of medullary cystic kidney disease type 2 (MCKD2) [MIM:603860]. MCKD2 is a form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade.
      Defects in UMOD are the cause of glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) [MIM:609886]. GCKDHI is a renal disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability.
    • 序列相似性Contains 3 EGF-like domains.
      Contains 1 ZP domain.
    • 细胞定位Cell membrane. Secreted. Secreted after cleavage in the urine.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ADMCKD2 antibody
      • FJHN antibody
      • HNFJ antibody
      • HNFJ1 antibody
      • MCKD2 antibody
      • medullary cystic kidney disease 2 (autosomal dominant) antibody
      • Tamm Horsfall glycoprotein antibody
      • Tamm Horsfall urinary glycoprotein antibody
      • Tamm-Horsfall urinary glycoprotein antibody
      • THGP antibody
      • THP antibody
      • Umod antibody
      • Urehd1 antibody
      • urehr4 antibody
      • UROM_HUMAN antibody
      • uromodulin (uromucoid, Tamm-Horsfall glycoprotein) antibody
      • Uromodulin antibody
      • Uromodulin, secreted form antibody
      see all

    Anti-Uromucoid antibody (ab9029)参考文献

    ab9029 has not yet been referenced specifically in any publications.

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