Anti-Uromucoid抗体(ab53588)

概述

  • 产品名称Anti-Uromucoid抗体
    参阅全部 Uromucoid 一抗
  • 描述
    羊多克隆抗体to Uromucoid
  • 经测试应用适用于: ELISA, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Human Uromucoid, purified from urine

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 0.1% EACA, 0.01% Benzamidine, Glycine buffered saline, 1mM EDTA, pH 7.4
  • Concentration information loading...
  • 纯度Ammonium Sulphate Precipitation
  • 纯化说明Ig fraction prepared by ammonium sulphate fractionation.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab53588 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/10000 - 1/40000.
IHC-Fr 1/50 - 1/200.

靶标

  • 功能Not known. May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
  • 组织特异性Synthesized by kidney. Most abundant protein in normal human urine.
  • 疾病相关Defects in UMOD are the cause of familial juvenile hyperuricemic nephropathy type 1 (HNFJ1) [MIM:162000]. HNFJ1 is a renal disease characterized by juvenil onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.
    Defects in UMOD are the cause of medullary cystic kidney disease type 2 (MCKD2) [MIM:603860]. MCKD2 is a form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade.
    Defects in UMOD are the cause of glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI) [MIM:609886]. GCKDHI is a renal disorder characterized by a cystic dilation of Bowman space, a collapse of glomerular tuft, and hyperuricemia due to low fractional excretion of uric acid and severe impairment of urine concentrating ability.
  • 序列相似性Contains 3 EGF-like domains.
    Contains 1 ZP domain.
  • 细胞定位Cell membrane. Secreted. Secreted after cleavage in the urine.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ADMCKD2 antibody
    • FJHN antibody
    • HNFJ antibody
    • HNFJ1 antibody
    • MCKD2 antibody
    • medullary cystic kidney disease 2 (autosomal dominant) antibody
    • Tamm Horsfall glycoprotein antibody
    • Tamm Horsfall urinary glycoprotein antibody
    • Tamm-Horsfall urinary glycoprotein antibody
    • THGP antibody
    • THP antibody
    • Umod antibody
    • Urehd1 antibody
    • urehr4 antibody
    • UROM_HUMAN antibody
    • uromodulin (uromucoid, Tamm-Horsfall glycoprotein) antibody
    • Uromodulin antibody
    • Uromodulin, secreted form antibody
    see all

Anti-Uromucoid antibody (ab53588)参考文献

ab53588 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. This product is partially purified by ammonium sulfate precipitation. Due to the nature of this purification, an exact concentration can not be determined. However, an estimate of specific antibody present in this prepa...

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