功能The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
序列相似性Belongs to the WD repeat STRAP family. Contains 7 WD repeats.
细胞定位Cytoplasm. Nucleus. Localized predominantly in the cytoplasm but also found in the nucleus.
Serine-threonine kinase receptor-associated protein antibody
serine/threonine kinase receptor associated protein antibody
UNR-interacting protein antibody
WD 40 repeat protein PT WD antibody
WD-40 repeat protein PT-WD antibody
Anti-Unrip antibody 图像
Immunocytochemistry/ Immunofluorescence - Anti-Unrip antibody (ab102001)This image is courtesy of an anonymous Abreview
ab102001 staining Unrip in human primary fibroblasts by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with paraformaldehyde, permeabilized with 0.2% Triton X-100 and blocked with 2% BSA for 1 hour at room temperature. Samples were incubated with primary antibody (1/500 in PBS + 2% BSA) for 2 hours. An Alexa Fluor® 488-conjugated goat anti-rabbit IgG polyclonal (1/500) was used as the secondary antibody.