Use at an assay dependent concentration. PubMed: 23232257
功能Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
组织特异性Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
序列相似性Belongs to the unc-5 family. Contains 1 death domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 2 TSP type-1 domains. Contains 1 ZU5 domain.
翻译后修饰Phosphorylated on cytoplasmic tyrosine residues. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
细胞定位Cell membrane. Membrane raft. Associated with lipid rafts.
p53 regulated receptor for death and life antibody
p53 regulated receptor for death and life protein 1 antibody
p53-regulated receptor for death and life protein 1 antibody
Protein unc-5 homolog 2 antibody
Protein unc-5 homolog B antibody
Protein XUNC 5 antibody
Transmembrane receptor Unc5H2 antibody
Unc 5 homolog 2 antibody
Unc 5 homolog B antibody
Unc 5 netrin receptor B antibody
UNC 5B antibody
Unc5 (C.elegans homolog) b antibody
Anti-UNC5B antibody 图像
Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-UNC5B antibody (ab104871)Image from Liao S et al., Neuroscience, 231, 225-32. Fig 3.; doi: 10.1016/j.neuroscience.2012.11.059.
Immunohistochemical analysis of paraformaldehyde-perfusion fixed Rat brain tissue, staining UNC5B (red) with ab104871 at 1/300 dilution.
Anti-UNC5B antibody (ab104871)参考文献
This product has been referenced in:
Liao SJ et al. Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats. Neuroscience231:225-32 (2013).
Read more (PubMed: 23232257) »
Westenskow PD et al. Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting. J Clin InvestN/A:N/A (2013).
Read more (PubMed: 24084735) »