概述

  • 产品名称Anti-UNC5B抗体
    参阅全部 UNC5B 一抗
  • 描述
    兔多克隆抗体to UNC5B
  • 经测试应用适用于: WB, ELISA, ICC/IF, IHC-FoFrmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse
  • 免疫原

    UNC5B Human recombinant protein.

性能

应用

Our Abpromise guarantee covers the use of ab104871 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/5000. Predicted molecular weight: 104 kDa.
ELISA Use at an assay dependent concentration.
ICC/IF 1/100 - 1/500.
IHC-FoFr Use at an assay dependent concentration. PubMed: 23232257

靶标

  • 功能Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906). Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
  • 组织特异性Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
  • 序列相似性Belongs to the unc-5 family.
    Contains 1 death domain.
    Contains 1 Ig-like (immunoglobulin-like) domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 2 TSP type-1 domains.
    Contains 1 ZU5 domain.
  • 翻译后修饰Phosphorylated on cytoplasmic tyrosine residues.
    Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
    Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
  • 细胞定位Cell membrane. Membrane raft. Associated with lipid rafts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 6330415E02Rik antibody
    • A630020F16 antibody
    • D10Bwg0792e antibody
    • Netrin receptor UNC5B antibody
    • Netrin receptor UNC5B Precursor antibody
    • p53 regulated receptor for death and life antibody
    • p53 regulated receptor for death and life protein 1 antibody
    • p53-regulated receptor for death and life protein 1 antibody
    • p53RDL1 antibody
    • Protein unc-5 homolog 2 antibody
    • Protein unc-5 homolog B antibody
    • Protein XUNC 5 antibody
    • Transmembrane receptor Unc5H2 antibody
    • Unc 5 homolog 2 antibody
    • Unc 5 homolog B antibody
    • Unc 5 netrin receptor B antibody
    • UNC 5B antibody
    • Unc5 (C.elegans homolog) b antibody
    • Unc5b antibody
    • UNC5B_HUMAN antibody
    • UNC5H2 antibody
    see all

Anti-UNC5B antibody 图像

  • Immunohistochemical analysis of paraformaldehyde-perfusion fixed Rat brain tissue, staining UNC5B (red) with ab104871 at 1/300 dilution.

     

Anti-UNC5B antibody (ab104871)参考文献

This product has been referenced in:
  • Liao SJ  et al. Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats. Neuroscience 231:225-32 (2013). IHC-FoFr ; Rat . Read more (PubMed: 23232257) »
  • Westenskow PD  et al. Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting. J Clin Invest N/A:N/A (2013). IHC ; Mouse . Read more (PubMed: 24084735) »

See all 2 Publications for this product

Product Wall

There are currently no Abreviews or Questions for ab104871.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"