Mouse, Rat, Zebrafish
Recombinant protein fragment corresponding to a region within amino acids 680 and 927 of Human UNC13B (NP_006368)
293T, H1299, HeLa or HepG2 cell lysate.
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7
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Immunogen affinity purified
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/500 - 1/3000. Predicted molecular weight: 181 kDa.
Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
Expressed in kidney cortical epithelial cells and brain.
Belongs to the unc-13 family.
Contains 3 C2 domains. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 MHD2 (MUNC13 homology domain 2) domain. Contains 1 phorbol-ester/DAG-type zinc finger.
The C2 domains are not involved in calcium-dependent phospholipid binding.
Cytoplasm. Membrane. Cell membrane. Cell junction > synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.
Information by UniProt
has not yet been referenced specifically in any publications.
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