概述

  • 产品名称
  • 描述
    兔多克隆抗体to UNC13B
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Zebrafish
  • 免疫原

    Recombinant protein fragment corresponding to a region within amino acids 462 and 719 of Human UNC13B (NP_006368)

  • 阳性对照
    • 293T and HeLa cells

性能

应用

Our Abpromise guarantee covers the use of ab97664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 181 kDa.

靶标

  • 功能
    Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses.
  • 组织特异性
    Expressed in kidney cortical epithelial cells and brain.
  • 序列相似性
    Belongs to the unc-13 family.
    Contains 3 C2 domains.
    Contains 1 MHD1 (MUNC13 homology domain 1) domain.
    Contains 1 MHD2 (MUNC13 homology domain 2) domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
  • 结构域
    The C2 domains are not involved in calcium-dependent phospholipid binding.
  • 细胞定位
    Cytoplasm. Membrane. Cell membrane. Cell junction > synapse. Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding.
  • Information by UniProt
  • 数据库链接
  • 别名
    • hmunc13 antibody
    • MGC133279 antibody
    • MGC133280 antibody
    • munc13 antibody
    • Munc13-2 antibody
    • Protein unc-13 homolog B antibody
    • UN13B_HUMAN antibody
    • unc-13 homolog B (C. elegans) antibody
    • UNC13 antibody
    • Unc13b antibody
    • Unc13h2 antibody
    see all

图片

  • Anti-UNC13B antibody (ab97664) at 1/5000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 181 kDa

实验方案

文献

ab97664 has not yet been referenced specifically in any publications.

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