概述

  • 产品名称Anti-ULK3抗体
    参阅全部 ULK3 一抗
  • 描述
    兔多克隆抗体to ULK3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Cow, Cat, Dog, Pig
  • 免疫原

    Synthetic peptide corresponding to a region within intracellular amino acids 281-330 (LGRATALVVQ AVKKDQEGDS AAALSLYCKA LDFFVPALHY EVDAQRKEAI) of Human ULK3 (NP_001092906).

  • 阳性对照
    • Jurkat cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab108261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Serine/threonine protein kinase which enhances GLI1 and GLI2 transcriptional activity and consequently positively regulates GLI-dependent SHH signaling. May exert this function by promoting GLI1 nuclear localization. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.
  • 组织特异性Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest expression in the hippocampus, high levels also detected in the cerebellum, olfactory bulb and optice nerve. In the central nervous system, lowest levels in the spinal cord.
  • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
    Contains 2 MIT domains.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated in vitro.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 形式There are 3 isoforms produced by alternative splicing.
  • 别名
    • DKFZP434C131 antibody
    • FLJ90566 antibody
    • Serine/threonine-protein kinase ULK3 antibody
    • Ulk3 antibody
    • ULK3_HUMAN antibody
    • unc 51 like kinase 3 (C. elegans) antibody
    • Unc-51-like kinase 3 antibody
    see all

Anti-ULK3 antibody 图像

  • Anti-ULK3 antibody (ab108261) at 1 µg/ml + Jurkat cell lysate at 10 µg

    Predicted band size : 53 kDa

Anti-ULK3 antibody (ab108261)参考文献

ab108261 has not yet been referenced specifically in any publications.

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