Anti-ULBP2抗体[MM0593-7F33] (ab89930)

概述

  • 产品名称
    Anti-ULBP2抗体[MM0593-7F33]
    参阅全部 ULBP2 一抗
  • 描述
    小鼠单克隆抗体[MM0593-7F33] to ULBP2
  • 经测试应用
    适用于: Neutralising, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Human ULBP2 protein

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Protein G purified
  • 纯化说明
    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter.
  • 克隆
    单克隆
  • 克隆编号
    MM0593-7F33
  • 同种型
    IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab89930 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Neutralising Use at an assay dependent concentration.
Flow Cyt 1/50 - 1/100. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能
    Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
  • 组织特异性
    Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues.
  • 序列相似性
    Belongs to the MHC class I family.
  • 细胞定位
    Cell membrane. Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ALCAN alpha antibody
    • ALCAN-alpha antibody
    • N2DL 2 antibody
    • N2DL-2 antibody
    • N2DL2 antibody
    • N2DL2_HUMAN antibody
    • NKG2D ligand 2 antibody
    • NKG2D ligand 2 precursor antibody
    • NKG2DL2 antibody
    • RAET1H antibody
    • Retinoic acid early transcript 1 H antibody
    • Retinoic acid early transcript 1H antibody
    • UL16 binding protein 2 antibody
    • UL16-binding protein 2 antibody
    • ULBP2 antibody
    see all

Anti-ULBP2 antibody [MM0593-7F33] (ab89930)参考文献

This product has been referenced in:
  • Chitadze G  et al. NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human ?d T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors. Oncoimmunology 5:e1093276 (2016). Flow Cyt . Read more (PubMed: 27141377) »
  • Fernández L  et al. In vitro Natural Killer Cell Immunotherapy for Medulloblastoma. Front Oncol 3:94 (2013). Flow Cyt ; Human . Read more (PubMed: 23626949) »

See all 2 Publications for this product

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The isotyp is IgG2a.
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