Anti-ULBP2抗体[MM0593-7F33] (ab89930)
Key features and details
- Mouse monoclonal [MM0593-7F33] to ULBP2
- Suitable for: Flow Cyt, Neutralising
- Reacts with: Human
- Isotype: IgG2a
概述
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产品名称
Anti-ULBP2抗体[MM0593-7F33]
参阅全部 ULBP2 一抗 -
描述
小鼠单克隆抗体[MM0593-7F33] to ULBP2 -
宿主
Mouse -
经测试应用
适用于: Flow Cyt, Neutralisingmore details -
种属反应性
与反应: Human -
免疫原
Recombinant Human ULBP2 protein
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter. -
克隆
单克隆 -
克隆编号
MM0593-7F33 -
同种型
IgG2a -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab89930于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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Flow Cyt |
Use at an assay dependent concentration.
ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
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Neutralising |
Use at an assay dependent concentration.
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说明 |
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Flow Cyt
Use at an assay dependent concentration. ab170191 - Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody. |
Neutralising
Use at an assay dependent concentration. |
靶标
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功能
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. -
组织特异性
Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. -
序列相似性
Belongs to the MHC class I family. -
细胞定位
Cell membrane. Secreted. - Information by UniProt
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数据库链接
- Entrez Gene: 80328 Human
- Omim: 605698 Human
- SwissProt: Q9BZM5 Human
- Unigene: 656778 Human
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别名
- ALCAN alpha antibody
- ALCAN-alpha antibody
- N2DL 2 antibody
see all
数据表及文件
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Datasheet download
文献 (3)
ab89930 被引用在 3 文献中.
- Chitadze G et al. In-depth immunophenotyping of patients with glioblastoma multiforme: Impact of steroid treatment. Oncoimmunology 6:e1358839 (2017). PubMed: 29147621
- Chitadze G et al. NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human ?d T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors. Oncoimmunology 5:e1093276 (2016). Flow Cyt . PubMed: 27141377
- Fernández L et al. In vitro Natural Killer Cell Immunotherapy for Medulloblastoma. Front Oncol 3:94 (2013). Flow Cyt ; Human . PubMed: 23626949