Anti-ULBP1抗体[MM0592-10K10] (ab89929)

概述

  • 产品名称Anti-ULBP1抗体[MM0592-10K10]
    参阅全部 ULBP1 一抗
  • 描述
    小鼠单克隆抗体[MM0592-10K10] to ULBP1
  • 经测试应用适用于: Neutralising, Flow Cytmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length Human protein.

  • 常规说明


    Suitable for neutralization of ligand-receptor interaction.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • Primary antibody说明Suitable for neutralization of ligand-receptor interaction.
  • 克隆单克隆
  • 克隆编号MM0592-10K10
  • 同种型IgG2a
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab89929 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Neutralising Use at an assay dependent concentration.
Flow Cyt 1/50 - 1/100. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

靶标

  • 功能Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
  • 组织特异性Expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver, testis, lymph node, thymus, tonsil and bone marrow. Also found in fetal heart, brain, lung and liver.
  • 序列相似性Belongs to the MHC class I family.
  • 细胞定位Cell membrane. Endoplasmic reticulum. Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Alcan beta antibody
    • ALCAN-beta antibody
    • N2DL-1 antibody
    • N2DL1 antibody
    • N2DL1_HUMAN antibody
    • NKG2D ligand 1 antibody
    • NKG2D ligand 1 precursor antibody
    • NKG2DL1 antibody
    • RAET1I antibody
    • Retinoic acid early transcript 1I antibody
    • UL16 antibody
    • UL16 binding protein 1 antibody
    • UL16-binding protein 1 antibody
    • ULBP1 antibody
    see all

Anti-ULBP1 antibody [MM0592-10K10] (ab89929)参考文献

ab89929 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab89929.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"