概述

  • 产品名称Anti-UHRF1抗体
    参阅全部 UHRF1 一抗
  • 描述
    兔多克隆抗体to UHRF1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    KLH conjugated synthetic peptide selected from the central region of Human UHRF1.

  • 阳性对照
    • HeLa cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab93419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/1000.
    WB: 1/100 - 1/500. Predicted molecular weight: 90 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
    • 组织特异性Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Contains 1 PHD-type zinc finger.
      Contains 2 RING-type zinc fingers.
      Contains 1 ubiquitin-like domain.
      Contains 1 YDG domain.
    • 发展阶段Expressed in fetal thymus, liver and kidney.
    • 结构域The RING finger is required for ubiquitin ligase activity.
      The YDG domain mediates the interaction with histone H3.
    • 翻译后修饰Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity.
      Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Ac2-121 antibody
      • AL022808 antibody
      • E3 ubiquitin-protein ligase UHRF1 antibody
      • EC 6.3.2.- antibody
      • FLJ21925 antibody
      • hNP95 antibody
      • hUHRF1 antibody
      • HuNp95 antibody
      • ICBP90 antibody
      • Inverted CCAAT box binding protein of 90 kDa antibody
      • Inverted CCAAT box binding protein, 90-kD antibody
      • Inverted CCAAT box-binding protein of 90 kDa antibody
      • Liver regeneration-related protein LRRG126 antibody
      • MGC138707 antibody
      • NP95 antibody
      • Nuclear phosphoprotein, 95-KD antibody
      • Nuclear protein 95 antibody
      • Nuclear zinc finger protein Np95 antibody
      • RING finger protein 106 antibody
      • RNF106 antibody
      • Transcription factor ICBP90 antibody
      • Ubiquitin like containing PHD and RING finger domains protein 1 antibody
      • Ubiquitin like PHD and RING finger domain containing protein 1 antibody
      • Ubiquitin-like PHD and RING finger domain-containing protein 1 antibody
      • Ubiquitin-like protein containing PHD and RING finger domains 1 antibody
      • Ubiquitin-like with PHD and ring finger domains 1 antibody
      • Ubiquitin-like, containing PHD and RING finger domains, 1 antibody
      • Ubiquitin-like-containing PHD and RING finger domains protein 1 antibody
      • UHRF1 antibody
      • UHRF1_HUMAN antibody
      see all

    Anti-UHRF1 antibody 图像

    • Anti-UHRF1 antibody (ab93419) at 1/100 dilution + HeLa cell lysate at 35 µg

      Predicted band size : 90 kDa

    Anti-UHRF1 antibody (ab93419)参考文献

    ab93419 has not yet been referenced specifically in any publications.

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