产品名称 Anti-UHRF1抗体 参阅全部 UHRF1 一抗
WB, ELISA more details
KLH conjugated synthetic peptide selected from the central region of Human UHRF1.
存放说明 Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
存储溶液 Preservative: 0.09% Sodium Azide
Concentration information loading...
纯度 Immunogen affinity purified
纯化说明 Purified through a protein A column, followed by peptide affinity purification.
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明 ELISA: 1/1000.
WB: 1/100 - 1/500. Predicted molecular weight: 90 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能 Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.
组织特异性 Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.
通路 Protein modification; protein ubiquitination.
序列相似性 Contains 1 PHD-type zinc finger. Contains 2 RING-type zinc fingers. Contains 1 ubiquitin-like domain. Contains 1 YDG domain.
发展阶段 Expressed in fetal thymus, liver and kidney.
结构域 The RING finger is required for ubiquitin ligase activity. The YDG domain mediates the interaction with histone H3.
翻译后修饰 Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity. Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage.
Information by UniProt
E3 ubiquitin-protein ligase UHRF1 antibody
Anti-UHRF1 antibody (ab93419)参考文献
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"