概述

  • 产品名称
    Anti-UGGT抗体[EPR5105]
    参阅全部 UGGT 一抗
  • 描述
    兔单克隆抗体[EPR5105] to UGGT
  • 经测试应用
    适用于: WB, IHC-Pmore details
    不适用于: Flow Cyt,ICC or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues in Human UGGT (Q9NYU2).

  • 阳性对照
    • Human skeletal muscle, BXPC-3, SH-SY5Y, and MCF7 lysates, Human brain tissue
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
  • 纯度
    Tissue culture supernatant
  • 克隆
    单克隆
  • 克隆编号
    EPR5105
  • 同种型
    IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab124879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/50000. Detects a band of approximately 170 kDa (predicted molecular weight: 177 kDa).
IHC-P 1/100 - 1/250.
  • 应用说明
    Is unsuitable for Flow Cyt,ICC or IP.
  • 靶标

    • 功能
      Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation.
    • 组织特异性
      Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart.
    • 通路
      Protein modification; protein glycosylation.
    • 序列相似性
      Belongs to the glycosyltransferase 8 family.
    • 结构域
      The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects.
    • 细胞定位
      Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment.
    • Information by UniProt
    • 数据库链接
    • 别名
      • GT antibody
      • HUGT1 antibody
      • UDP glucose glycoprotein glucosyltransferase 1 antibody
      • UDP Glucose Glycoprotein Glucosyltransferase antibody
      • UDP--Glc:glycoprotein glucosyltransferase antibody
      • UDP-glucose ceramide glucosyltransferase-like 1 antibody
      • UDP-glucose:glycoprotein glucosyltransferase 1 antibody
      • UGCGL1 antibody
      • UGGG1 antibody
      • UGGG1_HUMAN antibody
      • UGGT antibody
      • Uggt1 antibody
      • UGT1 antibody
      • UGTR antibody
      see all

    Anti-UGGT antibody [EPR5105] 图像

    • Staining of UGGT in Paraffin-embedded Human brain tissue by Immunohistochemistry using ab124879 at a dilution of 1/100.
    • All lanes : Anti-UGGT antibody [EPR5105] (ab124879) at 1/10000 dilution

      Lane 1 : Human skeletal muscle lysate
      Lane 2 : BXPC-3 cell lysate
      Lane 3 : SH-SY5Y cell lysate
      Lane 4 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 177 kDa

    Anti-UGGT antibody [EPR5105] (ab124879)参考文献

    This product has been referenced in:
    • Neerincx A  et al. TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway. Elife 6:N/A (2017). Read more (PubMed: 28425917) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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