概述

  • 产品名称
  • 描述
    兔多克隆抗体to UFD1L
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Recombinant fragment
    预测可用于: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to C terminal residues of UFD1L (Human)

性能

应用

Our Abpromise guarantee covers the use of ab56208 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.

靶标

  • 功能
    Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures.
  • 组织特异性
    Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney.
  • 通路
    Protein degradation; proteasomal ubiquitin-dependent pathway.
  • 序列相似性
    Belongs to the UFD1 family.
  • 细胞定位
    Nucleus. Cytoplasm > cytosol.
  • Information by UniProt
  • 数据库链接
  • 别名
    • UB fusion protein 1 antibody
    • Ubiquitin fusion degradation 1 like (yeast) antibody
    • Ubiquitin fusion degradation 1 like antibody
    • Ubiquitin fusion degradation protein 1 homolog antibody
    • UFD1 antibody
    • UFD1_HUMAN antibody
    • UFD1L antibody
    see all

实验方案

Anti-UFD1L antibody (ab56208)参考文献

ab56208 has not yet been referenced specifically in any publications.

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