概述

  • 产品名称Anti-UEV1A抗体
    参阅全部 UEV1A 一抗
  • 描述
    兔多克隆抗体to UEV1A
  • 特异性This antibody may also recognize isoform b of UEV1.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Xenopus laevis, Drosophila melanogaster, Zebrafish
  • 免疫原

    Synthetic peptide:

    TFTNQIHKWSHTYFGLPRW

    , corresponding to amino acids 31-49 of Human UEV1 (170 aa isoform a).

  • 阳性对照
    • Jurkat cell lysates. HeLa cell lysates. RAW (mouse) cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab46949 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1 - 3 µg/ml. Detects a band of approximately 20 kDa in Jurkat, RAW and HeLa cell lysates.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Ubiquitin-conjugating enzyme E2 (UEV1) was initially discovered as a protein similar in sequence and structure to the E2 ubiquitin-conjugating enzymes but lacking their enzymatic activity. There are at least two variants and multiple isoforms of UEV1. In particular, UEV1A (Ubiquitin-conjugating enzyme E2 variant 1 isoform A) has recently been shown to be an important component of the Toll-like receptor and IL-1R signaling pathway. Signals from these pathways are relayed by a number of downstream molecules such as MyD88 and tumor necrosis factor receptor associated factor (TRAF6), ultimately activating various kinases and transcription factors. UEV1A is part of a dimeric ubiquitin-conjugating enzyme complex also containing Ubc13 (ubiquitin-conjugating enzyme 13) that together with TRAF6 activates TAK1, a member of the mitogen-activated protein kinase kinase kinase family. The Ubc13-UEV1A complex also mediates the Lys-63 ubiquitination of TRAF-6, and this ubiquitination is essential for TAK1 activation.
    • 细胞定位Nuclear
    • 数据库链接
    • 别名
      • CIR1 antibody
      • CROC1 antibody
      • CROC1A antibody
      • DNA binding protein antibody
      • P/OKcl.19 antibody
      • TRAF6-regulated IKK activator 1 beta Uev1A antibody
      • UBE2V antibody
      • UBE2V1 antibody
      • Ubiquitin-conjugating enzyme E2 variant 1 antibody
      • UEV 1A antibody
      • UEV-1 antibody
      • UEV1 antibody
      • UEV1A antibody
      see all

    Anti-UEV1A antibody 图像

    • Anti-UEV1A antibody (ab46949) at 1 µg/ml + Jurkat cell lysate

      Observed band size : 20 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 97 kDa. We are unsure as to the identity of these extra bands.

    Anti-UEV1A antibody (ab46949)参考文献

    ab46949 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab46949.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"