概述

  • 产品名称Anti-UCHL3抗体
    参阅全部 UCHL3 一抗
  • 描述
    兔多克隆抗体to UCHL3
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide from an internal sequence of Human UCHL3, conjugated to KLH.

  • 阳性对照
    • Human testis tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab62035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 10 µg/ml.

靶标

  • 功能Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory.
  • 组织特异性Highly expressed in heart, skeletal muscle, and testis.
  • 序列相似性Belongs to the peptidase C12 family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ubiquitin carboxyl-terminal hydrolase isozyme L3 antibody
    • Ubiquitin thioesterase L3 antibody
    • Ubiquitin thiolesterase antibody
    • Ubiquitin thiolesterase L3 antibody
    • UCH L3 antibody
    • UCH-L3 antibody
    • UCHL3 antibody
    • UCHL3_HUMAN antibody
    see all

Anti-UCHL3 antibody 图像

  • ab62035 at 10µg/ml staining UCHL3 in human testis by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

Anti-UCHL3 antibody (ab62035)参考文献

ab62035 has not yet been referenced specifically in any publications.

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