概述

  • 产品名称Anti-UBXN6抗体
    参阅全部 UBXN6 一抗
  • 描述
    兔多克隆抗体to UBXN6
  • 经测试应用适用于: IP, IHC-Pmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residue 250 and 300 of human UBXN6 (NP_079517.1).

  • 阳性对照
    • HeLa whole cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: Tris citrate/phosphate, pH 7 to 8
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Antibody was affinity purified using an epitope specific to UBXN6 immobilized on solid support
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

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应用

Our Abpromise guarantee covers the use of ab103525 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
IHC-P 1/500 - 1/2000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Acts in a complex with VCP and cooperates with USP7 in promoting MDM2 deubiquitination and stabilization. MDM2 stabilization leads to MDM2-dependent TP53 degradation.
    • 组织特异性Enhanced expression in testis.
    • 序列相似性Contains 1 PUB (PUG) domain.
      Contains 1 UBX domain.
    • 结构域The UBX domain lacks key residues critical for VCP binding.
    • 细胞定位Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes at the centrosome both in interphase and during mitosis.
    • Information by UniProt
    • 数据库链接
    • 别名
      • UBX domain containing 1 antibody
      • UBX domain containing 2 antibody
      • UBX domain containing protein 1 antibody
      • UBX domain containing protein 6 antibody
      • UBX domain protein 6 antibody
      • UBX domain-containing protein 1 antibody
      • UBX domain-containing protein 6 antibody
      • UBXD1 antibody
      • UBXDC2 antibody
      • Ubxn6 antibody
      • UBXN6_HUMAN antibody
      see all

    Anti-UBXN6 antibody 图像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling UBXN6 with ab103525 at 1/1000 (1µg/ml). Detection: DAB.
    • Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. (1) ab103525 used for IP at 3 µg/mg lysate. (2) Control IgG Chemiluminescence with an exposure time of 10 seconds.

    Anti-UBXN6 antibody (ab103525)参考文献

    ab103525 has not yet been referenced specifically in any publications.

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