概述

  • 产品名称Anti-UBR1抗体
    参阅全部 UBR1 一抗
  • 描述
    小鼠单克隆抗体to UBR1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: ADEEAGGTER MEISAELPQT PQRLASWWDQ QVDFYTAFLH HLAQLVPEIY FAEMDPDLEK QEESVQMSIF TPLEWYLFGE DPDICLEKLK HSGAFQLCG, corresponding to amino acids 2-101 of Human UBR1

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG1
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab58117 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
    • 组织特异性Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
    • 通路Protein modification; protein ubiquitination.
    • 疾病相关Defects in UBR1 are a cause of Johanson-Blizzard syndrome (JBS) [MIM:243800]. This disorder includes congenital exocrine pancreatic insufficiency, multiple malformations such as nasal wing aplasia, and frequent mental retardation. Pancreas of individuals with JBS do not express UBR1 and show intrauterine-onset destructive pancreatitis.
    • 序列相似性Belongs to the UBR1 family.
      Contains 1 RING-type zinc finger.
      Contains 1 UBR-type zinc finger.
    • 发展阶段Expressed in fetal pancreas.
    • 结构域The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Cytoplasm > cytosol.
    • Information by UniProt
    • 数据库链接
    • 别名
      • E3 ubiquitin-protein ligase UBR1 antibody
      • JBS antibody
      • N-recognin-1 antibody
      • ubiquitin protein ligase E3 component n-recognin 1 antibody
      • Ubiquitin-protein ligase E3-alpha-1 antibody
      • Ubiquitin-protein ligase E3-alpha-I antibody
      • UBR1 antibody
      • UBR1_HUMAN antibody
      see all

    Anti-UBR1 antibody 图像



    • Predicted band size : 200 kDa
      UBR1 antibody (ab58117) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-UBR1 antibody (ab58117)参考文献

    ab58117 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab58117.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"