概述

  • 产品名称Anti-Ubiquilin抗体
    参阅全部 Ubiquilin 一抗
  • 描述
    兔多克隆抗体to Ubiquilin
  • 经测试应用适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Hamster, Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide corresponding to Mouse Ubiquilin aa 2-18.
    Sequence:

    AESAESGGPPGAQDSAA

  • 阳性对照
    • CHO cell extract.

性能

应用

Our Abpromise guarantee covers the use of ab3341 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 63 kDa.

By Western blot, this antibody detects an ~63 kDa protein representing Ubiquilin from CHO cell extract.

IHC-P Use at an assay dependent concentration.
ICC/IF Use a concentration of 1 µg/ml. PubMed: 19112176

靶标

  • 功能Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation.
  • 组织特异性Ubiquitous. Highly expressed throughout the brain; detected in neurons and in neuropathological lesions, such as neurofibrillary tangles and Lewy bodies. Highly expressed in heart, placenta, pancreas, lung, liver, skeletal muscle and kidney.
  • 序列相似性Contains 1 UBA domain.
    Contains 1 ubiquitin-like domain.
  • 结构域Binds PSEN1 and PSEN2 via its UBA domain.
  • 翻译后修饰Phosphorylated.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DA41 antibody
    • DSK2 antibody
    • FLJ90054 antibody
    • hPLIC-1 antibody
    • hPLIC1 antibody
    • PLIC-1 antibody
    • PLIC1 antibody
    • Protein linking IAP with cytoskeleton 1 antibody
    • Ubiquilin-1 antibody
    • Ubiquilin1 antibody
    • UBQL1_HUMAN antibody
    • UBQLN1 antibody
    • UBQN antibody
    • XDRP1 antibody
    see all

Anti-Ubiquilin antibody 图像



  • Predicted band size : 63 kDa

    Western blot detection of Ubiquilin on CHO cell extract using ab3341.

Anti-Ubiquilin antibody (ab3341)参考文献

This product has been referenced in:
  • Adusei DC  et al. Early developmental alterations in GABAergic protein expression in fragile X knockout mice. Neuropharmacology 59:167-71 (2010). WB ; Mouse . Read more (PubMed: 20470805) »
  • Hiltunen M  et al. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem 281:32240-53 (2006). ICC/IF ; Mouse . Read more (PubMed: 16945923) »

See all 2 Publications for this product

Product Wall

Abreviews
Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Loading amount 50 µg
Gel Running Conditions Reduced Denaturing
Sample Human Cell lysate - whole cell (U2OS)
Specification U2OS
Blocking step Milk as blocking agent for 30 minute(s) · Concentration: 5% · Temperature: 22°C
Username

Dr. Randal Tibbetts

Verified customer

提交于 May 23 2013

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"