概述

  • 产品名称Anti-UBE2V1抗体
    参阅全部 UBE2V1 一抗
  • 描述
    兔多克隆抗体to UBE2V1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Chicken, Cow, Orangutan
  • 免疫原

    Synthetic peptide:

    GTVSWGLEDD EDMTLTRWT

    conjugated to KLH, corresponding to amino acids 31-49 of Human UBE2V1 (NP_954595.1)

  • 阳性对照
    • Human thyroid tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab89903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 26 kDa.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
  • 组织特异性Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.
  • 序列相似性Belongs to the ubiquitin-conjugating enzyme family.
  • 细胞定位Nucleus. Excluded from the nucleolus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CIR1 antibody
    • CROC-1 antibody
    • CROC1 antibody
    • CROC1A antibody
    • TRAF6-regulated IKK activator 1 beta Uev1A antibody
    • UB2V1_HUMAN antibody
    • UBE2V 1 antibody
    • UBE2V antibody
    • UBE2V1 antibody
    • Ubiquitin conjugating enzyme E2 variant 1 antibody
    • Ubiquitin-conjugating enzyme E2 variant 1 antibody
    • UEV-1 antibody
    • UEV1 antibody
    see all

Anti-UBE2V1 antibody 图像

  • ab89903 at 5µg/ml staining UBE2V1 in Human thyroid by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue.

Anti-UBE2V1 antibody (ab89903)参考文献

ab89903 has not yet been referenced specifically in any publications.

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